摘要
目的考察不同内酯型比例羟喜树碱(HCPT)对H22肝癌模型小鼠的抗肿瘤作用。方法构建H22肝癌小鼠模型,观察不同内酯型(0%,25%,50%,75%,100%)比例HCPT对肿瘤的抑制率以及给药前后小鼠的生长状况,测定血清生化指标,考察不同内酯型比例HCPT对小鼠肝肾功能的影响。结果阳性药和不同内酯比例HCPT对肿瘤均有抑制作用,抑制率分别为65.30%,12.57%,49.23%,75.47%,90.06%,93.22%;与模型对照组比较,不同内酯型比例组小鼠生存状况均有改善。随着内酯型比例增加,小鼠肝损伤明显减轻,但肾脏损伤程度增加。结论 HCPT内酯型比例与抗肿瘤药效呈正相关,内酯型比例约75%有较好的抗肿瘤药效,且毒性较比例为100%内酯型更低。
Objective To investigate the anti-tumor effects of hydroxycamptothecin （HCPT） with different lactone ratios on the mice models of H22 hepatoma. Methods Mice models of H22 hepatoma were established. Tumor inhibiting rates of HCPT with different laetone ratios （ 0%, 25% , 50%, 75% , 100% ） and the growth status of model mice before and after chemotherapy were observed. Serum biochemical indices were determined to investigate the effects of HCPT with different laetone ratios on hepatic and renal function of the mice. Results Positive control drug and HCPT with different lactone ratios all inhibited the tumor in mice with I-I22 hepatoma, the inhibition rate was 65.30%, 12.57%, 49.23%, 75.47%, 90.06% and 93.22% , respectively. Compared with the model control group, the living conditions of the mice in HCFI＇ groups were improved. With increasing of laetone ratios, the hepatic injury was alleviated markedly, but the renal injury was aggravated. Conclusion There is a positive correlation between lactone ratios and its anti-tumor effect, and HCPT with 75% lactone can achieve preferable anti-tumor effect with less toxicity as compared with that with 100% lactone ratio.
出处
《医药导报》
CAS
2015年第4期471-475,共5页
Herald of Medicine
关键词
羟喜树碱
H22小鼠模型
内酯型比例
药效学
Hydroxycamptothecin
Mouse model of H22 hapatoma
Lactone ratio
Pharmacodynamics
