摘要
目的观察降钙素原(PCT)在肝硬化并发肝肾综合征(HRS)患者中的水平变化。方法选取肝硬化患者143例为观察对象,根据其并发HRS情况分为2组:非HRS组115例、HRS组28例,同时以健康体检者40例作为对照组。所有待测者均测定血清PCT、C反应蛋白(CRP)、胱抑素-C(Cys-C)、白细胞计数、中性粒细胞比例、血肌酐及尿肌酐水平,比较各组的上述指标变化情况,分析血清PCT水平与HRS发病率,以及其与CRP、Cys-C、24 h内生肌酐清除率(24 h-Ccr)的相关性。结果PCT升高患者的HRS发生率明显高于PCT正常患者(P=0.026)。血清PCT、CRP、Cys-C,HRS组>非HRS组>对照组(均P<0.05);24 h-Ccr,HRS组<非HRS组<对照组(均P<0.05),血清PCT水平与CRP、Cys-C水平呈正相关,与24 h-Ccr呈负相关(P<0.05)。结论检测PCT水平有助于肝硬化患者感染及肾功能损害的早期判断,在HRS诊疗中具有重要意义。
Objective To observe changes of procalcitonin （PCT） level in cirrhosis patients complicated with hepatorenal syn？drome （HRS）. Methods Cirrhosis without HRS （Non-HRS group, n=115）, cirrhosis with HRS （HRS group, n=28） and control group （40 cases） were enrolled. Levels of serum PCT, C-reactive protein （CRP）, Cystatin-C （Cys-C）, white blood count, percentage of neutro？phils, serum creatinine and urine creatinine were examined in all participants. Correlation between serum PCT levels and incidence of HRS was analyzed. Correlations between serum PCT levels with CRP, Cys-C, 24 h-Creatinine clearance （24 h-Ccr） were analyzed. Re？sults Among cirrhosis patients, those with increased PCT had higher chance of complication with HRS than those with normal PCT （P=0.026）. Levels of serum PCT, CRP and Cys-C are higher in HRS Group than those in Non-HRS group,both which are higher than those incontrol group （P〈0.05）;Level of 24 h-Ccr is lower in HRS Group than that in non-HRS group, both of which are lower than that in control group （P〈0.05）. Levels of serum PCT positively correlated to levels of serum CRP and Cys-C but, negatively correlated to levels of 24 h-Ccr. Conclusion Serum PCT level contribute to early infection and renal damage in cirrhosis and might play an im？portant role in development of HRS. It is valuable in giving early information of cirrhosis complicated with HRS.
出处
《天津医药》
CAS
2015年第4期393-395,共3页
Tianjin Medical Journal
关键词
肝肾综合征
肝硬化
降钙素
降钙素原
胱抑素-C
hepatorenal syndrome
liver cirrhosis
calcitonin
procalcitonin
cystatin-C
