摘要
目的：观察Ⅰ~Ⅱ期乳腺癌保乳手术后辅助放化疗的效果。方法：Ⅰ~Ⅱ期乳腺癌患者65例,行乳腺癌保留乳房手术治疗,术后采用蒽环类或紫杉类药物为主的联合化疗,辅助放疗采用调强放疗技术行全乳房照射;观察患者辅助放化疗的毒副反应、乳房美容效果、局部复发、远处转移及生存情况。结果：随访12~78个月,4年生存率为100%,3例发生远处转移（4.6%）,放疗主要急性毒副反应为Ⅰ~Ⅱ度皮肤反应（87.7%）及Ⅰ度骨髓抑制（46.1%）,化疗主要毒副反应表现为Ⅰ~Ⅱ度骨髓抑制（86.4%）、Ⅰ~Ⅱ度消化道反应（88.1%）及Ⅱ~Ⅲ度脱发（74.6%）;乳房美容效果优良57例（88%）;不满意者8例（12%）。结论：Ⅰ~Ⅱ期乳腺癌患者行保乳手术后辅助放化疗疗效肯定,毒副反应可以耐受,治疗结束后乳房满意度良好。
Objective： To observe the effect of adjuvant chemoradiation in breast cancer with stage Ⅰ~ Ⅱ after breast conservative surgery（ BCS）. Methods： Sixty-five patients of breast cancer（ Ⅰ ~Ⅱ） received treatment of breast conservative surgery and the combination chemotherapy of anthracycline or taxane were adopted in postoperative therapy. The intensity modulated radiotherapy（ IMRT）was used for the whole breast irradiation in adjuvant radiotherapy. The toxicity and side reactions,breast cosmetic result,local recurrence,distant metastasis and overall survival situation were observed. Results： After follow-up of 12 to 78 months,it was observed that 4-year survival rate was100%,of which 3 cases appeared distant metastasis（ 3 /65,4. 6%）. In radiotherapy the major acute toxicity and side reactions were Ⅰ ~ Ⅱ degree skin reactions（ 87. 7%） and Ⅰ degree myelo suppression（ 46. 1%）. The main side effects of chemotherapy wereⅠ~ II degree myelo suppression（ 86. 4%）,Ⅰ~ Ⅱdegree gastrointestinal reactions（ 88. 1%） and Ⅱ~ Ⅲ degree hair loss（ 74. 6%）. In breast cosmetic result,57 cases were excellent,accounting for 88%. 8 cases were unsatisfactory,accounting for12%. Conclusions： The curative effect is certain for Ⅰ ~ Ⅱ stage breast cancer treated with BCS plus adjuvant chemoradiation. The toxic and side effects are mild and the breast cosmetic result is satisfactory.
出处
《贵阳医学院学报》
CAS
2015年第3期288-290,共3页
Journal of Guiyang Medical College
关键词
乳腺肿瘤
放射疗法
计算机辅助
化学疗法
辅助
外科手术
保乳
预后
breast cancer
radiotherapy
computer-assisted
chemotherapy
assisted
breast conservative surgery
prognosis
