摘要
目的:比较盐酸戊乙奎醚和阿托品用于开胸手术术前用药对呼吸和循环功能的影响。方法:80例ASA分级I-II级全麻下行开胸手术患者,随机分成两组,P组(盐酸戊乙奎醚组)和A组(阿托品组),每组40例。每组患者麻醉诱导前分别给予盐酸戊乙奎醚0.01mg/kg,或阿托品0.01mg/kg,分别记录插管后切皮前(T1)、单肺通气后30min(T2)、单肺通气后60min(T3)、恢复双肺通气后15min(T4)的气道峰压(Ppeak)、气道平台压(Pplat)、肺顺应性(Compl)、气道压力(Paw)以及各时点血压、心率和血气参数变化。结果:P组患者在T2、T3、T4时肺顺应性降低的幅度及气道峰压、气道平台压、气道阻力升高的幅度明显低于A组(P<0.05)。P组在T2、T3、T4时Sa O2明显高于A组(P<0.05)。T2、T3时A组心率显著高于P组。结论:盐酸戊乙奎醚可以改善患者呼吸功能,血流动力学稳定,作用时间长,比阿托品更适合用于开胸手术术前用药。
Objective： To compare the effects of penehyclidine hydrochloride and atropine on respiratory and circulatory function in patients with thoracic surgery. Methods： Eighty pations with ASAI or II treated with thoracic surgery were randomly divided into two groups（ group P and group A） with 40 patients in each groups. Group P received penehyclidine hydrochloride（ group P〈0. 01 mg / kg） group A was administered with atropine（ group A 0. 01 mg / kg）. Mean artery pressure and heart rate were recorded,the arterial blood samples were taken and Ppeak,Pplat,Compl,Paw were recorded at the time point of before operation（ T1）,30min（ T2）,60min（ T3） after one- lung ventilation,15 min after double lung ventilation（ T4）. Results： The Compl,Ppeak,Pplat,Compl and Paw in group P was significantly lower than in group A at T2,T3,T4（ P〈0. 05）,Sa O2 in group P was significantly higher than in group A at T2,T3,T4（ P〈0. 05）. Heart rate was lower in group P than group A at T2 and T3（ P〈0. 05）. Conclusion： Compared with atropine,penehyclidine hydrochloride can effectively improve respiratory fuction,the hemodynamics is more stable and effect is longer,which is more suitable for patients ungergoing thoracic surgery.
出处
《现代肿瘤医学》
CAS
2015年第7期986-988,共3页
Journal of Modern Oncology
关键词
盐酸戊乙奎醚
阿托品
开胸手术
单肺通气
呼吸循环功能
penehyclidine hydrochloride
atropine
thoracic surgery
one lung vention
respiratory and circulatory function
