摘要
目的:探讨GOLPH3蛋白在食管癌组织中的表达情况。方法:采用免疫组织化学方法检测97例食管癌组织中GOLPH3蛋白的表达情况,分析GOLPH3蛋白与食管癌的临床病理特征的关系。结果:GOLPH3蛋白的表达主要位于细胞质,呈黄褐色,在正常食管黏膜组织和食管癌组织差别有统计学意义(P=0.001)。GOLPH3蛋白的表达差异与食管癌患者的年龄(P=0.34>0.05)、性别(P=0.38>0.05)和病理类型(P=2.74>0.05)没有统计学意义;与食管癌的分化程度(P=0.00<0.05)、淋巴结转移(P=0.01<0.05)和临床病理分期(P=0.04<0.05)有统计学意义。结论:GOLPH3可能在肿瘤形成、分化、增殖和转移过程中起了非常重要的作用。
Objective:To detect the expression of GOLPH3 in esophageal carcinoma and normal esophageal tissue. Methods:We performed the immunohistochemistry to detect the expression GOLPH3 protein in 97 patients with esophageal carcinoma. The clinical pathological significance and expression features were evaluated in 97 patients. Results:GOLPH3 protein was expressed in normal and tumor esophageal epithelium. There was a significant difference in GOLPH3 expression(P = 0. 001) between them. Moreover,there were significant correlations between the expression of GOLPH3 and differentiation( P = 0. 00),lymph node metastasis( P = 0. 01) and pathologic stages( P = 0. 04) of EC. Conclusion:The increased expression of GOLPH3 may play an important role in the development of esophageal carcinoma.
出处
《现代肿瘤医学》
CAS
2014年第9期2112-2114,共3页
Journal of Modern Oncology
关键词
GOLPH3蛋白
食管癌
免疫组化
GOLPH3 protein
esophageal carcinoma
immunohistochemistry
