摘要
目的:研究结直肠癌组织中CD151及整合素α6的表达,探讨他们与结直肠癌临床病理因素及上皮间质转化(epithelial-mesenchymal transition,EMT)的关系.方法:132例结直肠癌制成2张组织芯片,以30例癌旁组织作对照,采用免疫组织化学检测其中CD151、整合素α6及E-钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)的表达,分析比较前两种蛋白与结直肠癌临床病理因素之间的关系及其与上皮间质表达标志物之间的关系.结果:结直肠癌组织中CD151及整合素α6表达阳性率分别为65.9%和75.7%,均高于癌旁组织;CD151和整合素α6的表达均与肿瘤浸润深度及淋巴结转移密切相关;CD151在结直肠癌中表达还与E-cadherin的低表达、Vimentin的高表达密切相关.结论:CD151和整合素α6通过促进EMT促进结直肠癌浸润转移,为研究结直肠癌EMT发生机制提供新的思路,同时为CD151作为肠癌的靶向治疗指标提供理论依据.
AIM：To investigate the relationship between CD151 and Integrin α6 expression and clinicopathological parameters in colorectal cancer,and analyze the role of the two proteins in epithelial-mesenchymal transition（EMT）.METHODS：Immunohistochemistry was performed to detect the expression of CD151,Integrin α6,E-cadherin and Vimentin in132 colorectal cancer specimens using tissue microarray.RESULTS：The positive rates of CD151 and Integrin α6 in colorectal cancer tissues were65.9%and 75.7%,respectively,significantly higher than those in tumor-adjacent normal tissues.CD151 and Integrin α6 expression was closely related with the depth of invasion and lymph lode metastasis,while the expression of CD151 was closely associated with low E-cadherin expression and high Vimentin expression.CONCLUSION：CD151 may accelerate the invasion and metastasis of colorectal cancer by promoting EMT.
出处
《世界华人消化杂志》
CAS
2015年第5期852-856,共5页
World Chinese Journal of Digestology
基金
上海市教委科研基金资助项目
No.2011JW59~~
