摘要
目的对2010—2013年常州地区手足口病病原体检出情况进行分析。方法选取2010年1月—2013年12月常州地区1945例手足口病患儿的肛拭子和咽拭子标本。用实时荧光定量聚合酶链反应对所有标本进行肠道病毒核酸检测,比较不同年份、不同年龄组、不同性别、不同部位标本检出的病原体型别分布及总阳性率。结果 1945例手足口病患儿中,检出肠道病毒（enterovirus,EV）71型591例（30.39%）,柯萨奇病毒A组（coxasckievirus A,Cox A）16型526例（27.04%）,其他肠道病毒476例（24.47%）。不同年份病原体型别分布不同（P〈0.05）：2010和2012年以Cox A16型最多,EV71次之;2011年以EV71最多,Cox A16型次之;2013年以非EV71、Cox A16其他的EV型最多,EV71型次之。在总体阳性率方面,除1~岁组高于0~岁组外,其余各组间差异均无统计学意义。不同年龄组3种病原体型别分布差异具有统计学意义,其中0~岁组和1~岁组均以非EV71、Cox A16型最多,EV71次之,Cox A16最少;3~岁组和6~岁组均以EV71最多,Cox A16型次之,非EV71、Cox A16的其他EV型最少。肛拭子组阳性率显著高于咽拭子组。结论 EV71和Cox A16型是2010—2013年常州地区手足口病主要病原体,3~6岁儿童是高发人群,肛拭子总阳性检出率高于咽拭子。
Objective To analyze the pathogens of hand, foot and mouth disease（HFMD） in Changzhou from 2010 to 2013.Methods Both rectal and throat swab samples from 1945 HFMD children in Changzhou from Jan. 2010 to Dec. 2013 were selected.The real-time fluorescence PCR was applied to detect nucleic acids of enteroviruses, and the genotype distribution according to year,age, gender and sample type, and the positive rate were analyzed statistically. Results Of 1945 HFMD patients, 591 patients（30.39%）were found positive for enterovirus（EV） 71, 526 patients（27.04%） for coxasckievirus A（Cox A） 16, and 476 patients（24.47%） for other EVs. The genotype distribution according to year was significantly different. In 2010 and 2012, the positive rate of Cox A16 was the highest, followed by that of EV71; in 2011, the positive rate of EV71 was the highest, followed by that of Cox A16; in 2013, the positive rate of non-Cox A16/EV71 was the highest, followed by that of EV71. The total positive rate of 1~ age group was higher than that of 0~ age group, but the differences were not significant among the other age groups. There were significant differences in the distribution of the three genotypes among the different age groups. The positive rate of non-Cox A16/EV71 was the highest, followed by that of EV71 in 0~and 1~ age groups, and the positive rate of EV71 was the highest, followed by that of and Cox A16 in 3~ and 6~ age groups. The positive detection rate in rectal swab group was significantly higher than that in throat swab group. Conclusions EV71 and Cox A16 are predominant pathogens of HFMD in Changzhou from 2010 to 2013. HFMD mainly occurs in children at the age of 3-6 years. The positive detection rate of rectal swab samples is significantly higher than that of throat swab samples.
出处
《传染病信息》
2015年第1期25-27,共3页
Infectious Disease Information
基金
常州市卫生局指导课题(WZ201125)
关键词
肠道病毒属
病原
手足口病
流行病学研究
enterovirus
noxae
hand
foot and mouth disease
epidemiologic studies
