摘要
溃疡性结肠炎(ulcerative colitis,UC)又称慢性非特异性溃疡性结肠炎,流行病学资料提示溃疡性结肠炎的发病率在国内外都有逐年增高的趋势,溃疡性结肠炎的研究越来越受到国际肠病学家的关注,所以建立接近于人类的稳定的溃疡性结肠炎动物模型尤为重要。本文综述了近几年常用的诱发溃疡性结肠炎动物模型的化学方法及评价,以期为基础与临床研究应用提供参考。
Ulcerative colitis（UC） is also known as chronic nonspecific ulcerative colitis. Epidemiological data suggest that the incidence of ulcerative colitis both in domestic and abroad has increased annually,thus attracting increasing research attention. Establishing valid animal models of ulcerative colitis seems particularly critical. In this review,animal models of ulcerative colitis were reviewed in the hope to provide guidance for related basic and clinical research.
出处
《神经药理学报》
2013年第4期23-28,共6页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.81274005)
关键词
溃疡性结肠炎
动物模型
制备方法
评价
ulcerative colitis
animal models
preparation methods
evaluation
