摘要
A new binuclear copper complex, [Cu2L2（pht）2]2·H2O （Hpht = 5,5-diphenylhy- dantoin, i.e. phenytoin; L = 2-diethylaminoethanol）, has been synthesized by the solvothermal method, and characterized by elemental analysis, IR and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 31.918（3）, b = 12.9222（15）, c = 19.868（2） A,β = 98.762（2）°, V= 8098.8（16） A3, Dc = 1.429 Mg/m3, Z= 4, F（000） = 3640, p = 1.107 mm-1, R = 0.0560 and wR = 0.1276 （1 〉 20（/））. Each copper（Ⅱ） in a molecule is coordinated with N and O atoms from ligand L and N atom from ligand Hpht in a tetradentate manner. Moreover, two copper（Ⅱ） centers are bridged by two O atoms of hydroxyl groups from two L ligands to form a slightly distorted binuclear {Cu202} diamond configuration. In addition, the interaction of this complex with calf thymus DNA （CT-DNA） was investigated by UV-vis spectrum and viscometry, and the complex may bind to DNA through intercalation.
A new binuclear copper complex, [Cu2L2（pht）2]2·H2O （Hpht = 5,5-diphenylhy- dantoin, i.e. phenytoin; L = 2-diethylaminoethanol）, has been synthesized by the solvothermal method, and characterized by elemental analysis, IR and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 31.918（3）, b = 12.9222（15）, c = 19.868（2） A,β = 98.762（2）°, V= 8098.8（16） A3, Dc = 1.429 Mg/m3, Z= 4, F（000） = 3640, p = 1.107 mm-1, R = 0.0560 and wR = 0.1276 （1 〉 20（/））. Each copper（Ⅱ） in a molecule is coordinated with N and O atoms from ligand L and N atom from ligand Hpht in a tetradentate manner. Moreover, two copper（Ⅱ） centers are bridged by two O atoms of hydroxyl groups from two L ligands to form a slightly distorted binuclear {Cu202} diamond configuration. In addition, the interaction of this complex with calf thymus DNA （CT-DNA） was investigated by UV-vis spectrum and viscometry, and the complex may bind to DNA through intercalation.
基金
supported by the National Natural Science Foundation of China(No.21101069)
Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(13KJB150005)
the Open Foundation of Jiangsu Key Laboratory of Marine Biotechnology(No.HS12006)
the Priority Academic Program Development of Jiangsu Higher Education Institutions
