摘要
目的探讨非小细胞肺癌(NSCLC)不同临床分期血小板参数变化对肺癌远处转移的预测价值。方法回顾性分析2013年4月至2014年1月就诊于该院诊治住院的肺癌患者,分别检测患者血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、大血小板比例(P-LCR)及血小板压积(PCT)等参数。结果检测结果显示肺癌组PLT、MPV、P-LCR和PCT均高于肺部良性肿瘤组及健康对照组,差异有统计学意义(P<0.01),而PDW比较差异无统计学意义(P>0.05)。随TNM分期的增加,Ⅲ期(血小板增高比例32.35%)和Ⅳ期(42.85%)明显高于Ⅰ期(19.35%)和Ⅱ期(22.85%)(P<0.01)。Ⅳ期血小板五项参数与Ⅰ期、Ⅱ期比较,差异均有统计学意义(P<0.05);但Ⅲ期与Ⅰ期、Ⅱ期PDW和P-LCR比较,差异无统计学意义(P>0.05)。Ⅳ期与Ⅲ期PLT、MPV和PCT比较,差异均有统计学意义(P<0.05)。结论肺癌患者常以某种特殊机制刺激骨髓巨核细胞产生血小板,分期愈晚血小板增高比例越明显,连续动态观察血小板参数有助于临床判断病情的发展及预后。
Objective To investigate the predictive value of platelet parameters on distant metastasis of different clinical stages of non‐small cell lung cancer （NSCLC） .Methods A retrospective analysis was performed on the inpatients with lung cancer in our hospital from April 2013 to January 2014 .The parameters of platelet count （PLT ） ,mean platelet volume （MPV） ,platelet distribu‐tion width （PDW） ,platelet ‐large cell ratio（P‐LCR） ,platelet hematocrit （PCT ） ,etc .were detected respectively .Results The re‐sults showed that PLT ,MPV ,P‐LCR and PCT in the lung cancer group were higher than those in the benign lung tumor group and the healthy control group ,the differences were statistically significant （P〈 0 .01） ,while PDW had no statistically significant differ‐ence among these groups（P〉0 .05） .With the TNM stage increase ,the increased platelet proportion in the stage Ⅲ and Ⅳ was sig‐nificantly higher than that in the stage Ⅰ and Ⅱ （32 .35% ,42 .85% vs .19 .35% ,22 .85% ,P〈0 .01） .The platelet five parameters in the stage Ⅳ had statistical difference compared with those in the stage Ⅰ and Ⅱ （P〈 0 .05） ;but PDW and P‐LCR in the stage Ⅲhad no statistical difference compared with those in the stage Ⅰ and Ⅱ （P〉0 .05） ;PLT ,MPV and PCT in the stage Ⅳ had statisti‐cal difference compared with those in the stage Ⅲ （P〈0 .05） .Conclusion The patients with lung cancer often stimulate the bone marrow megakaryocytes to produce platelets by a particular mechanism .As the staging increase ,the proportion of increased platelet is more obvious .Continuously and dynamically observing platelet parameters is conducive to judge the development and prognosis of the disease .
出处
《国际检验医学杂志》
CAS
2015年第6期729-730,733,共3页
International Journal of Laboratory Medicine
基金
云南省教育厅科学研究资助项目(2013Y299)
关键词
非小细胞肺癌
血小板参数
远处转移
non-small cell lung cancer
platelet parameters
distant metastasis
