摘要
[目的]探讨活血退黄经验方用于婴儿胆汁淤积性肝病的疗效。[方法]2012年11月~2014年4月选取98例诊断为婴儿胆汁淤积性肝病的患儿,随机分成治疗组及对照组各49例,治疗组又按照中医证候分型分为寒湿阻滞证（Ⅰ组）及气滞血瘀证（Ⅱ组）两个亚组。其中对照组采用西医常规治疗,治疗组在对照组的基础上加用桃红四物汤合茵陈蒿汤加减而成的活血利胆经验方,疗程均为4周,于治疗前后观察患儿皮肤巩膜黄染、大小便颜色等临床症状及体征以及血清总胆红素（TBIL）、直接胆红素（DBIL）、谷丙转氨酶（ALT）、总胆汁酸（TBA）、肝脏彩超等实验室指标变化情况,并进行疗效及积分评价。[结果]2组治愈率及总有效率比较,差异有统计学意义（P〈0.05）;治疗组组间治愈率及总有效率比较,差异无统计学意义（P〉0.05）;治疗后,治疗组TBIL、DBIL、TBA及肝脏彩超实验室指标均明显下降,差异有统计学意义（P〈0.05）,而ALT与对照组比较,差异无统计学意义（P〉0.05）;治疗后,2组中医证候积分比较,差异有统计学意义（P〈0.05）,治疗组组间中医症候积分差值比较,差异有统计学意义（P〈0.05）。[结论]活血退黄经验方对Ⅰ型及Ⅱ型ICH均有显著疗效,对II型ICH中医证候疗效优于Ⅰ型。
[Objective]To explore the curative effect of empirical prescription of promoting blood circulation and relieving jaundice for infantile cholestatic hepatopathy（ICH）.[Methods]From November 2012 to April 2014,98 cases of ICH were randomly divided into control group（49cases）and treatment group（49cases）.According to TCM Syndrome Classification,the treatment group was divided into two sub-groups：the stagnation of cold damp syndrome（group Ⅰ）and the stagnation of Qi and blood stasis syndrome（groupⅡ）.The control group received routine treatment of western medicine.On the basis of which the treatment group was additionally given empirical prescription of promoting blood circulation and relieving jaundice with Taohong Siwu Decoction combining with Yinchenhao Decoction.The therapeutic course was 4weeks.Before and after treatment,the clinical symptoms,signs and laboratory indexes were observed.The curative effect and integral evaluation were also conducted.[Results]The clinically cured rate and total effective rate between two groups were significantly different（P〈0.05）;The comparison of cure rate and total efficiency between the two sub-groups was not significantly different（P〉0.05）;Except ALT,the other laboratory index as the TBIL,DBIL,TBA and liver ultrasound of treatment group decreased significantly after treatment.Compared with the control group,TCM syndrome integral was obviously different intreatment group（P〈0.05）.The difference of TCM syndrome integral between treatment sub-groups was also significant（P〈0.05）.[Conclusion]The empirical prescription of promoting blood circulation and relieving jaundice is effective for both type I and type II ICH.The effect is better in the stagnation of Qi and blood stasis type than the satagnation of cold damp type.
出处
《中国中西医结合消化杂志》
CAS
2015年第3期192-195,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
活血利胆经验方
婴儿胆汁淤积性肝病
疗效观察
empirical prescription of promoting blood circulation and relieving jaundice
infantile cholestatic hepatopathy
clinical observation
