摘要
用环磷酰胺、植物血凝素调节巨噬细胞的活性,观察了伯喹脂质体的抗疟效果。经注射环磷酰胺(200mg/kg)的伯喹脂质体组,小鼠肝组织单位面积(cm^2)疟原虫红外期数为0 211667±0.143961,疟原虫平均直径(A.M.D)为11.8350±1.84021μm;伯喹组单位面积(cm^2)红外期数为0.61425±0.35730,疟原虫平均直径为16.0418±4.8604μm,两组有显著性差异(P<0.05)。伯喹脂质体组与注射植物血凝素的伯喹脂质体组的抗疟效果未见提高。提示巨噬细胞活性的改变可影响伯喹脂质体的抗疟效果。
In the study mice were given primaquine (PQ) or primaqulne—liposome (PQ—Lip) 3 hours before Plasmodium goelii yoelii sporozoite inoculation and 3,12 hours after sporozoite inoculation.Parasitemia of the mice was determined on the 7th and 14th day after the inoculation by Giemsa stained blood smears.NO dif- ference was found between the PQ group and PQ—Lip group. Number (/cm^2) of exoerythrocytic forms (EES) in the liver of infected mice was counted 48 hours af- ter intravenous inoclation of sporozoites,and the average diameter (AMD) and length of the EES were de- termined and no significant difference Was found between PQ—Lip and PQ groups(P>0.05)But when the mlee were rejected intraperitoneally with cyclophosphamide (CP) 200mg/kg 27 hours before sporozoite inoculation,the number (/cm^2) of EES,A.M.D and length of EES were 0.21167±0.143961,11.8350 ±1. 8402μm and 12.9477±1.92415μm respectively.In the PQ group,the corresponding figures were 0. 61425±0.35730,16.0418±4.860 and 16.9923±5.64189μm There was significant difference be- tween the PQ—Lip group injected with CP and PQ group (P<0.05).No significant difference was found between PQ—Lip group injected with phytohemagglutinin and PQ group.
出处
《中国寄生虫病防治杂志》
CSCD
1991年第3期173-175,共3页
Chinese Journal of Parasitic Disease Control
