摘要
目的探讨慢性肾脏病（CKD）患者不同时期血脂各指标及D-二聚体水平的变化规律及相关危险因素。方法回顾性分析2010年2月至2014年1月收治的285例门诊及住院CKD患者（CKD组）的临床资料,根据CKD分期将其分为A组（CKD1-2期患者）、B组（CKD3-4期患者）、C组（CKD5期患者）,各95例;另选取212例体检健康者作为对照组。比较分析血脂水平、血脂紊乱情况的差异,并对相关危险因素进行分析。结果 CKD患者三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平高于对照组,组间比较差异均有统计学意义（P〈0.05）;组间高密度脂蛋白胆固醇（HDL-C）、极低密度脂蛋白胆固醇（VLDL-C）水平比较差异无统计学意义（P〉0.05）。A组患者HDL-C、VLDL-C水平及血脂正常者所占百分率（7.37%）分别高于B、C组,B组患者TG、TC、LDL-C水平及高脂血症发生率（87.37%）分别高于A、C组,C组患者D-二聚体水平及低脂血症发生率（14.74%）分别高于A、B组,差异均有统计学意义（P〈0.05）。血肌酐、D-二聚体水平和患者性别为女是CKD患者血脂异常的独立影响因素。结论 CKD患者高脂血症的发生率均较健康人群高,血肌酐、D-二聚体水平和患者性别为女是CKD患者血脂异常的独立影响因素。
Objective To investigate the change rule of blood lipids indexes,D-dimer level and the related risk factors in the patients with different periods of chronic kidney diseases（CKD）.Methods The clinical data in 285 outpatients and inpatients with CKD in our hospital from Feb.2010 to Jan.2014 as the CKD group were performed the retrospective analysis.These patients were divided into the group A（CKD stage 1-2）,B（CKD stage 3-4）and C（CKD stage 5）according to the CKD staging,95 cases in each group.Other 212 individuals of healthy physical examination were selected as the control group.The blood lipids levels and differences of blood lipids disorder situation were compared among groups and the related risk factors were analyzed.Results The TG,TC and LDL-C levels in the CKD patients were significantly higher than those in the control group with statistical differences between the two groups（P〈0.05）;the HDL-C and VLDL-C levels had no statistical difference between the two groups（P〉0.05）.The HDL-C and VLDL-C levels and the percentage（7.37%）of the patients with normal blood lipids levels in the group A were higher than those in the group B and C;the TG,TC and LDL-C levels and the occurrence rate（87.37%）of high hyperlipidemia in the group B were higher than those in the group A and C,the D-dimer level and the occurrence rate（14.74%）of hypolipidemia in the group C were higher than those in the group A and B,the differences were statistically significant（P〈0.05）.Serum creatinine,D-dimer and female were the independent influence factor of blood lipids in the patients with CKD.Conclusion The patients with CKD may have the high occurrence rate of hyperlipidemia than the healthy population.Serum creatinine,D-dimer and female are the independent factors of blood lipids in CKD patients.
出处
《检验医学与临床》
CAS
2015年第6期734-736,共3页
Laboratory Medicine and Clinic
基金
广西壮族自治区桂林市科技项目(20090535)
关键词
慢性肾脏病
脂质紊乱
相关性
chronic kidney disease
lipid disorder
correlation
