摘要
类风湿关节炎(rheumatoid arthritis,RA)是一种系统性慢性炎症性疾病,其基本病理特征是关节滑膜炎及血管翳形成。炎症是RA发生发展的基础和核心,但其炎症免疫机制尚不明确,本专题围绕RA的炎症及骨免疫代谢机制进行探讨,证实T细胞、B细胞、促炎因子网络及趋化因子均参与发病。此外,滑膜细胞、成骨细胞、破骨细胞等骨关节相关的结构细胞作为免疫调控下游的效应细胞,也广泛参与RA的炎症进展。RA的炎症与疾病活动性密切相关,对目前用于RA病情评估的多种方法进行比较,有利于规范应用及优化病情评估工具,从而制定治疗决策,改善患者预后。
Rheumatoid arthritis（RA）is a systemic chronic inflammatory disease with synovitis and pannus formation as its basic pathologic features.Immune mediated inflammation is the core event in the occurrence and development of RA,but the inflammatory mechanism in RA pathogenesis remains unclear and needs more research to be illustrated.T cells,B cells,proinflammatory cytokine network and chemokines were confirmed to be involved in the process.In addition,the cells related to the structure of bone and joint,such as synovial cells,osteoblasts and osteoclasts,also participate in the inflammation progression of RA acting as the effector cells of immune regulation.The severity of inflammation of RA is closely related to disease activity.There are many kinds of tools for the assessment of disease activity of RA.The rationale use and optimization of these assessment tools will be helpful to make the treatment decision and improve the prognosis of RA.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2015年第2期267-271,158,共5页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81172869及No.30901339)
四川省应用基础项目(No.2010JY0011)
四川省科技攻关项目(No.2009SZ0173)资助
关键词
风湿关节炎
炎症
发病机制
病情评估
Rheumatoid arthritis
Inflammation
Pathogenesis
Disease assessment
