摘要
目的：探讨影响老年子宫颈癌患者术后生存的影响因素。方法：对1980年1月-1998年12月诊治的老年子宫颈癌243例临床资料和随访结果进行回顾性分析。采用Kaplan-Meier法计算累积生存率,用Log-Rank法比较各因素不同水平生存分布的差异,进一步应用COX回归模型进行预后因素分析。结果：全组子宫颈癌术后5、10、15年累积生存率分别为87%、81%、75%,Log-Rank分析结果显示不同临床分期、不同组织分化程度、有无淋巴结转移、不同治疗方法患者生存差异存在明显差异（χ^2=23.172,P〈0.05;χ^2=32.766,P〈0.05;χ^2=25.086,P〈0.05;χ^2=28.906,P〈0.05）。年龄、不同生长方式、肿瘤直径、有无辅助治疗水平间生存差异无统计学意义（P〉0.05）,COX模型多因素分析表明：临床分期、组织分化程度、淋巴结转移是影响预后的独立因素（P〈0.01）。结论：临床分期、淋巴结转移、组织分化是影响老年子宫颈癌预后的独立危险因素,及早发现和合理降低临床分期是治疗老年子宫颈癌以及提高预后的关键手段。
Objective：To explore the influence factors of postoperative survival in elderly patients with cervical cancer.Methods：Clinical data of 243 elderly cases of cervical cancer were retrospectively analyzed during January 1980-December 1998.The Kaplan-Meier method was used to calculate the cumulative survival rate,Log-Rank method was used to compare the difference between the various factors of different level survival distribution,and COX regression model was used to analyze prognostic factors.Results：The whole set of cervical cancer for 5years,10 years,15years after the cumulative survival rate were87%,81%and 87%respectively.The Log-Rank analysis results showed that the difference of survival rate between the different clinical stage and tissue differentiation degree,with or without lymph node metastasis,different treatment was significant（Chi-square= 23.172,P〈0.05,Chi-square=32.766,P〈0.05,Chi-square=25.086,P〈0.05,Chi-square=28.906,P〈0.05）.There was no significant difference in survival rate between age,different growth way,the tumor diameter,survival difference between with and without auxiliary treatment（P〈0.05）,multi-factors COX model analysis showed that the clinical stage,tissue differentiation degree and lymph node metastasis were independent factors affecting the prognosis（P〈0.01）.Conclusions：Clinical stages,lymph node metastasis,differentiation were independent risk factors influencing the prognosis of elderly cervical cancer,early detection and reasonably reduce clinical stage are the key to treat elderly cervical cancer and improve the prognosis.
出处
《海南医学院学报》
CAS
2015年第4期565-567,570,共4页
Journal of Hainan Medical University
基金
张家口市科学技术研究与发展指导计划项目(1021071D)~~
关键词
老年
子宫颈癌
手术
放疗
预后
存活率
Old age
Cervical cancer
Surgery
Radiation therapy
Prognosis
Survival Rate
