摘要
目的观察亚叶酸钙治疗胰腺癌化疗患者反复口腔溃疡的疗效并探讨其护理方案。方法将64例胰腺癌化疗合并口腔溃疡患者随机分为对照组和观察组,各32例。对照组使用复方氯己定漱口,观察组在对照组基础上加用亚叶酸钙漱口。分别观察两组疗效、普食恢复及溃疡痊愈时间,同时观察治疗过程中不良反应发生情况。结果两组治疗后黏膜反应均较前显著改善,且观察组改善水平明显优于对照组(P<0.05),治疗总有效率显著高于对照组(P<0.05),普食和口腔溃疡恢复时间均短于对照组,且差异显著(P<0.05),不良反应发生率也显著低于对照组(P<0.05)。结论亚叶酸钙治疗胰腺癌化疗患者反复口腔溃疡安全、有效。
Objective To investigate the effect and nursing plan of leucovorin calcium in the treatment of recurrent oral ulcer due to pancreatic cancer chemotherapy. Methods 64 patients with pancreatic cancer chemotherapy complicating oral ulcer were randomly divided into the control group and the observation group,32 cases in each group. The control group used compound chlorhexidine for gargling,while on this basis the observation group was added with leucovorin calcium. The curative effects,normal diet recovery,ulcer healing time and occurrence situation of adverse reactions were observed and compared between the two groups. Results The mucosal reaction after treatment in the two groups was significantly improved compared with before treatment,moreover the improvement level in the observation group was superior to the control group（ P 0. 05）, the total effective rate in the observation group was significantly higher than that in the control group（ P 0. 05）,the recovery time of normal diet and oral ulcer in the observation group was significantly shorter than that in the control group（ P 0. 05）. In addition,the occurrence rate of adverse reactions in the observation group was significantly lower than that in the control group（ P 0. 05）. Conclusion Leucovorin calcium is safe and effective in the treatment of oral ulcer due to pancreatic cancer chemotherapy.
出处
《中国药业》
CAS
2015年第5期50-51,共2页
China Pharmaceuticals
关键词
亚叶酸钙
胰腺癌
口腔溃疡
护理干预
calcium folinate
pancreatic cancer
oral ulcer
nursing intervention
