摘要
目的：探究大黄对危重病患者胃肠功能衰竭及多器官功能障碍综合征（MODS）的防治作用。方法：选取2013年1月~2014年5月住院部收治的入住重症加强护理病房（ICU）的158例危重病患者作为研究对象,依据防治方式的不同将患者分为研究组79例和对照组79例。两组患者分别使用精黄片和生理盐水进行预防;并发应激性溃疡、中毒性肠麻痹和多器官功能障碍综合征后均使用精黄片进行治疗。观察并比较两组患者并发应激性溃疡、中毒性肠麻痹和多器官功能障碍综合征的情况,以及使用精黄片进行治疗的临床效果。结果：两组患者并发应激性溃疡、中毒性肠麻痹及多器官功能障碍综合征的发生率比较,研究组明显低于对照组,3项并发症结果组间比较P值均〈0.05。并发胃肠功能衰竭的患者治疗后胃肠功能衰竭的持续时间研究组为（1.7±0.3）d,对照组为（4.2±2.5）d,研究组明显短于对照组。两组患者并发多器官功能障碍综合征经治疗后存活28天以上者,研究组15例中存活了11例,占73.33%,对照组29例中存活了14例,占48.28%,差异具有统计学意义,研究组明显高于对照组。结论：精黄片用于防治危重病患者的胃肠功能衰竭及多器官功能障碍综合征疗效显著,不仅可以降低并发胃肠功能衰竭和多器官功能障碍综合征的发生率,且能有效提高患者并发多器官功能障碍综合征后的存活率。
Objective： To explore the rhubarb on gastrointestinal failure in critically ill patients, and multiple organ dysfunction syndrome （MODS） rats. Methods： January 2013 - May 2014 admitted to the inpatient stay Intensive Care Unit （ICU） of the 158 cases of critically ill patients as research subjects, based on different ways of prevention and treatment of patients into the study group and the control group 79 cases 79 ca- ses. Two groups of patients were using rhubarb and saline for prevention ; both stress ulcer after use, toxic intestinal paralysis and MODS rhu- barb （Rheum purification tablets, tradename fine yellow tablets） for treatment. Comparison of the two groups were observed and stress ulcer, toxic intestinal paralysis cases and MODS, and the use of rhubarb treatment of clinical effect. Results： The two groups of patients with stress ulcer, toxic intestinal paralysis and incidence of MODS, the study group was significantly lower than the control group, the result of complica- tions between the three groups were X2 = 9.70,4.13,7.99, P value 〈 0.05, the difference was statistically significant. Patients with gastro- intestinal failure after failure in the treatment of gastrointestinal duration of the study group （ 1.7 ± 0.3 ） d, the control group （4.2 ± 2.5 ） d, tile study group was significantly shorter than the control group, between groups t = 8.82, P 〈 0.05. Two groups of patients were treated after concurrent MODS survive more than 28 days were 15 patients in the study group survived 11 cases, accounting for 73.33%, 29 cases in the control group survived for 14 cases, accounting for 48.28%, between the two groups X2 = 13.01, P 〈 0.05, the difference was statistically significant, the study group was significantly higher. Conclusion： for the prevention and treatment of critically ill patients rhubarb gastroin- testinal failure and multiple organ dysfunction syndrome （MODS） a significant effect, not only can reduce concurrency gastrointestinal failure and incidence of MODS, and can effectively improve after the patients with MODS survival, worthy of clinical application.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第6期172-174,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
精黄片
胃肠功能衰竭
多器官功能障碍综合征
Rhubarb（大黄）
critically ill patients
gastrointestinal failure
multiple organ dysfunction syndrome
prophylaxis
