摘要
目的：建立氯沙坦钾片溶出度的紫外分光光度检查方法。方法：氯沙坦钾片在256nm处有最大吸收，采用紫外分光光度法测定其溶出度。结果：在10．32~41．28μg／mL的浓度范围内，氯沙坦钾片的浓度与它的吸收度之间呈良好的线性关系，回收率为（99．87％±0．83）％，RSD〈2％。结论：所建立的溶出度的测定方法的精密度、重现性考察等均符合规定，可用于控制制剂的质量。
Objective： To establish a method for determination of dissolution rate of losartan potassium tablets by UV spectrophotometry. Methods： After measuring the absorbance of losartan potassium tablets at 256 nm by UV spectrophotometry, dissolution rate was calculated. Results： In the range of 10.32~41.28μg/mL, there was a good linear relationship between concentration and absorbance of losartan potassium tablets, with the recovery rate of （99.87 ±0.83）%, and RSD〈2%. Conclusion： The established method is simple, sensitive and reliable, and can be utilized to control the quality oflosartan potassium tablets.
出处
《中医临床研究》
2014年第32期14-16,共3页
Clinical Journal Of Chinese Medicine
基金
广西壮族自治区卫生厅中医药科技专项课题(编号:GZZY13-03)
关键词
氯沙坦钾片
溶出度
紫外分光光度法
Losartan potassium tablets
Dissolution
UV spectrophotometry
