摘要
具有手性的氧代螺环异吲哚啉衍生物可作为天然药物的活性结构单元,这些化合物在医药和化工领域具有重要的研究价值。实验以1,4-二氧螺环[4.5]癸烷-8-酮和苯甲酸酐为原料,经过一系列反应制得2-(1-(4-氧代双环[4.1.0]庚基-1-)丙基-2-)异吲哚啉-1,3-二酮,并利用高效液相色谱(HPLC)、液质联用仪(LCMS)、核磁(NMR)对其结构进行表征。
Chiral oxo- and spiro- isoindoline derivatives serves as a bio-active structural unit of natural medicines, these compounds had important research value in pharmaceutical and chemical fields. In our experiment, we adopted 1,4-dioxaspiro[4. 5 ] decan-8 - one and phthalic anhydride as the raw material, 2-（1-（4-oxo-bicyclo [4. 1.0] hept- 1-） propyl-2-） isoindoline-1,3-dione were synthesized by a series of reactions, and the structure of these compouds were characterized by high- performance liquid chromatography （HPLC）, liquid chromatography- mass spectrometry （LCMS） , nuclear magnetic resonane spectrometry （NMR）.
出处
《广州化工》
CAS
2015年第4期87-89,共3页
GuangZhou Chemical Industry
基金
兴义民族师范学院院级课题资助项目(项目编号:13XYYZ02)
关键词
异吲哚类衍生物
天然药物
合成
表征
isoindoline derivative
natural medicines
synthesis
characterization
