摘要
目的:观察脾多肽联合放疗对中晚期食管癌近期临床疗效及其对免疫指标的影响。方法:将70例中晚期食管癌患者随机分为治疗组(放疗同期联合使用脾多肽)和对照组(单纯放疗)。分别检测患者T淋巴细胞亚群,同时观察疗效及毒副作用。结果:治疗组客观有效率91.43%,对照组客观有效率71.43%。治疗组客观有效率优于对照组(P<0.05),且治疗组治疗前后T淋巴细胞亚群有显著改善(P<0.01)。两组毒副作用相似(P>0.05)。结论:脾多肽联合放疗可提高中晚期食管癌的临床疗效并改善患者的免疫功能,但不减轻毒副作用。
Objective：To observe the influence of Lienapolypeptides on immunity index and clinical efficacy for patients with advanced esophugeal carcinoma during radiotherapy. Methods： All 70 cases with advanced esophugeal carcinoma were devided into treatment group （ radiotherapy accompanied by Lienapolypeptides ） and control group （radiotherapy）. Immunity index were measured pro - and - post treatment, clinical efficacy and side effect were ob- served. Results：The rencent response rate of treatment group were better than that of control group. T - lymphocite subsets were significantly improved after infusion of Lienapolypeptides. The side effect were similar in two groups. Conclusion：For patients with advanced esophugeal carcinoma, Lienapolypeptides combined with radiotherapy can im- prove clinical efficacy, and enhance immune function but did not reduce side effect.
出处
《现代肿瘤医学》
CAS
2015年第3期326-328,共3页
Journal of Modern Oncology
关键词
脾多肽
中晚期食管癌
放疗
Lienapolypeptides
advanced esophugeal carcinoma
radiotherapy
