摘要
目的 了解疗前血清LDH水平在鼻咽癌各放疗分型中分布及对预后影响.方法 搜集中山大学肿瘤防治中心2000-2005年初治鼻咽癌患者2665例资料,对疗前血清LDH检测值在放疗4种分型中变化及其与生存关系进行分析.结果 2 665例患者各放疗分型分布分别为Ⅰ型（放射敏感不易转移型）1 987例（74.6％）、Ⅱ型（放射抗拒不易转移型）404例（15.1％）、Ⅲ型（放射敏感易转移型）229例（8.6％）、Ⅳ型（放射抗拒易转型移型）45例（1.7％）.LDH升高者在4个分型所占比例分别为9.6％（191/1 987）、15.8％ （64/404）、18.8％（43/229）、35.6％（16/45）;Ⅲ、Ⅳ型转移患者共274例,其81例肝转移者中LDH升高者占42％（34例）.总随访率为95.2％.总体LDH升高组的OS、LRFS、DMFS曲线均差于LDH正常组（P=0.000、0.000、0.000）,而4个放疗分型中只有Ⅱ型OS的差异有统计学意义（P=0.000）.结论 疗前血清LDH水平升高与鼻咽癌放疗分型相关,在Ⅲ、Ⅳ型患者中LDH升高以肝转移更明显,LDH升高预后变差主要表现在Ⅱ型患者.
Objective This aim of this study was to understand the distribution of pretreatment serum LDH in NPC of each radiotherapy-related typing,and its relationship with prognosis.Methods We collected the pretreatment data of LDH in 2 665 newly diagnosed NPC who underwent radical radiotherapy between January 1,2000 and December 31,2005 at Sun Yat-sen University Cancer Center.Pretreatment serum LDH levels and survival analysis were analyzed in four kinds of radiotherapy-related typing of NPC.Results Distribution of radiotherapy-related types of 2 665 NPC were 74.6％ （1 987 cases）,15.1％ （404 cases）,8.6％ （229 cases）,1.7％ （45 cases） for Types Ⅰ （no primary and regional recurrence and no distant metastasis）,Ⅱ （primary or regional and no distant metastasis）,ⅢⅡ （no primary and regional recurrence,and distant metastasis）,Ⅳ （primary or regional recurrence,and distant metastasis）,respectively.Increased LDH patients Ⅰ,Ⅱ,Ⅲ,Ⅳ-type proportion were：9.6％ （191/1 987）,15.8％ （64/404）,18.8％ （43/229）,35.6％ （16/45）.274 cases of type Ⅲ and Ⅳ,there were 81 cases of liver metastasis,which increased LDH levels in 34 cases,accounted for 42％.Total follow-up rate was 95.2％.The OS,LRFS,and DMFS curves for the increased LDH level group and the normal LDH level group was significant （P =0.000,0.000,0.000）.Further analysis showed that the above main difference caused by the type Ⅱ （P =0.000）.Conclusions Pretreatment levels of serum LDH are associated with radiotherapyrelated typing of NPC,particularly associated with type Ⅲ and type Ⅳ liver metastasis.And mainly type Ⅱ has poor prognosis.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2015年第1期55-59,共5页
Chinese Journal of Radiation Oncology
关键词
鼻咽肿瘤/放射疗法
乳酸脱氢酶
预后
Nasopharyngeal neoplasms/radiotherapy
Lactate dehydrogense
Prognosis
