摘要
目的:探讨二甲双胍对慢性阻塞性肺病合并2型糖尿病患者血乳酸水平的影响。方法:回顾性分析2009年4月至2013年4月我院收治的60例2型糖尿病合并慢性阻塞性肺病的患者,观察患者在给予二甲双胍治疗前后血糖、肝肾功能、血乳酸等临床指标的变化及差异,患者住院时间、细菌培养等方面的差异。结果:研究组患者的血糖、血乳酸水平较治疗前显著好转,治疗后,与对照组比较差异明显,P<0.05;患者经二甲双胍治疗后住院时间减少,感染革兰氏阴性杆菌的例数有所下降。差异均有统计学意义(均P<0.05)。结论:二甲双胍治疗慢性阻塞性肺病合并2型糖尿病可以有效控制血乳酸水平,减少住院时间,控制革兰氏阴性杆菌的发生。
Objective：To explore the effect of metformin on blood lactic acid level of patients with chro-nic obstructive pulmonary disease complicated with type 2 diabetic. Method：60 cases of patients with chronic obstructive pulmonary disease and type 2 diabetes were selected with retrospective analysis from Apr. 2009 to Apr. 2013. Patients were observed in the variations of blood glucose, liver and kidney function, were given blood lactic acid and other clinical indicators before and after metformin treatment, then compared the differ-ences on hospitalization time and bacterial culture. Result：Blood sugar and blood lactic acid level in patients were significantly improved, the time staying in hospital and the number of infection of gram negative bacilli were reduced after being treated by metformin. Differences were statistically significant （ P 〈0.05） . Conclu-sion：Metformin in the treatment of chronic obstructive pulmonary disease complicated with type 2 diabetes can effectively control the blood lactic acid level, reduce the clinical hospital time, and control the gram neg-ative bacilli.
出处
《河北医学》
CAS
2015年第2期189-192,共4页
Hebei Medicine
基金
陕西省西安市卫生局立项
(编号:J2011005)
关键词
二甲双胍
慢性阻塞性肺病
2型糖尿病
血乳酸
Metformin
Chronic obstructive pulmonary disease
Type 2 diabetic
Lactic acid
