摘要
目的:探讨在宫颈癌中p-63、E-Cd(E-钙黏蛋白)和N-Cd(N-钙黏蛋白)的表达以及三者与宫颈癌之间的关系.方法:分析在本院接受手术治疗的131例宫颈鳞状细胞癌患者的宫颈癌组织标本。采用免疫组化SP法测定宫颈癌组织的p-63、E-Cd和N-Cd表达情况,探讨三者的表达两两之间是否存在相关性,并分析三者表达与宫颈癌组织的病理特征间的相关性。结果:E-cd表达阳性率为80.2%(105/131),N-cd表达阳性率为72.5%(95/131),p63阳性率为71.0%(93/131)。三者的表达两两之间均存在明显相关性(P<0.01);N-cd、E-cd、p63三者的阳性表达率与肿瘤组织的分化程度、临床分期、淋巴结转移情况以及5年生存率均存在相关性(P<0.05)。结论:p63、N-Cd和E-Cd在宫颈癌中三者表达两两之间具有相关性,且三者与宫颈癌的分化、分期、转移以及预后有着一定的相关性。
Objective： To study the expressions of p-63, E-cadherin and N-cadherin in cervical carcinoma and the corre- lation with the cervical carcinoma. Methods： Clinical data of patients with cervical squamous cell carcinoma admitted from 2004 to 2008 was retrospectively analyzed. Immuohistochemical assay was used to detect the expressions of p-63, E-cadherin and N- cadherin in cervical spuamous cell carcinoma tissues. The correlations of them were discussed. The relationship between their expressions and clinical tumor, pathological features was analyzed. Results： A total of 131cervical cancer specimens which from 131 patients with cervical carcinoma were retrospective analyzed. The positive expression rate of E-cd, N-cd and P63 in our study was separately 80.2%, 72.5% and 71.0%. There was correlation among E-cd, N-cd and P63（P〈0.01）. Expressions of N-cd, E-cd, p-63 were correlated with the extent of tissue differentiation, clinical stages, lymph node metastasis and the 5 year survival rate. Conclusions： The expressions of p-63, N-cd and E-cd have significant correlation with the differentiation of cervical cancer, stage, metastasis and prognosis has a certain relevance.
出处
《海南医学院学报》
CAS
2015年第2期155-157,共3页
Journal of Hainan Medical University
基金
2013年国家自然科学基金面上项目(81372805)~~
