摘要
目的 评价年龄因素对依托咪酯镇静效力的影响.方法 拟在全身麻醉下行择期手术患者150例,ASA分级Ⅰ或Ⅱ级,按年龄分为3组（n=50）,青年组（Y组）：18- 39岁;中年组（M组）：40-64岁;老年组（0组）：65-75岁.每组采用随机数字表法分为5个亚组（n=.10）：分别静脉注射依托咪酯0.07、0.09、0.11、0.13或0.17 mg/kg.注射后5 min内观察意识是否消失（睫毛反射消失）.结果 Y组、M组和O组依托咪酯使患者意识消失的半数有效剂量（ED50）分别为0.13、0.11和0.09mg/kg.与Y组比较,O组ED50降低（P＜0.05）,M组ED50差异无统计学意义（P＞0.05）.结论 年龄因素可影响依托咪酯镇静效力,依托咪酯对老年患者的镇静效力增强.
Objective To evaluate the influence of age factors on etomidate sedative potency.Methods One hundred and fifty （ASA physical status Ⅰ or Ⅱ） patients of both sexes,scheduled for elective operation under general anesthesia,were divided into 3 groups according to age （n =50 each）：group Y 18-44 yr,group M 40-64 yr and group O 65-75 yr.Each group was randomly divided into 5 subgroups receiving in＇venous etomidate 0.07,0.09,0.11,0.13 and 0.17 mg/kg,respectively.Loss of consciousness was evaluated depending on loss of eyelash reflex within 5 min after intravenous administration.Results ED50 of etomidate inducing loss of consciousness was 0.13,0.11 and 0.09 mg/kg in group Y,M and O,respectively.Compared with that in group Y,ED50 was significantly decreased in group O,however,and showed no significant change in group M.Conclusion Age factors can affect sedative potency of etomidate,which appears greater in the elderly patients.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2014年第12期1458-1459,共2页
Chinese Journal of Anesthesiology
关键词
年龄因素
依托咪酯
清醒镇静
Aged factors
Etomidate
Conscious sedation
