摘要
目的 报道2例皮肤黏液表皮样癌的临床病理特点.方法 对2例皮肤黏液表皮样癌进行病理检查,通过HE染色、黏液-糖元染色（AB-PAS）和免疫组化观察,结合文献进行分析.结果 2例肿瘤均位于皮下,可见表皮样细胞、中间细胞排列成片状、巢状,部分区域有大小不一的腺管结构,内衬黏液柱状上皮;肿瘤边界尚清,无明显包膜,周围呈浸润性生长.免疫组化染色示肿瘤细胞癌胚抗原（CEA）、细胞角蛋白（高分子）[CK（H）]、细胞角蛋白（低分子）[CK（L）]阳性表达.AB-PAS染色,黏液细胞胞质呈蓝色,黏液染色阳性.结论 皮肤原发性黏液表皮样癌是一种来源于附属器的恶性肿瘤,诊断依赖于组织学及免疫组化标记.
Objective To describe the clinicopathologic features of two cases of mucoepidermoid carcinoma of the skin.Methods Two cases of mucoepidermoid carcinoma of the skin were analyzed histopathologically using hematoxylin and eosin （HE） staining,alcian blue-periodic acid Schiff （AB-PAS） staining and immunohistochemical staining.Relavant literature was reviewed.Results Histopathological examination showed that the tumor was subcutaneously located in both cases,with epidermoid cells and intermediate cells arranged in sheets or nests,as well as different sizes of glandular structures lined by mucinous columnar epithelium in some areas.Both tumors had a relatively clear boundary with peripheral invasive growth and no obvious capsules.Immunohistochemical examination showed positive staining for carcinoembryonic antigen （CEA）,high and low molecular weight cytokeratin （CK（H） and CK（L））.The cytoplasm of mucous cells was stained blue with,and mucus was visualized after,AB-PAS staining.Conclusions Primary mucoepidermoid carcinoma of the skin is a kind of malignant tumor arising from skin appendages,whose diagnosis depends on histological and immunohistochemical examination.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2014年第12期896-898,共3页
Chinese Journal of Dermatology
关键词
癌
黏液表皮样
病例报告
Carcinoma, mucoepidermoid
Case reports
