摘要
目的:对小剂量瑞芬太尼在全身麻醉后抑制气管拔管心血管反应的临床效果展开研究分析。方法:将240例需行全身麻醉的急诊手术患者随机分为观察组和对照组,各120例,两组均给予相同的麻醉诱导和麻醉维持,术后观察组持续泵注小剂量瑞芬太尼,对照组输注生理盐水,记录比较两组患者拔管各时段血流动力学指标、麻醉恢复指标及不良反应。结果:观察组拔管即刻、拔管后1 min、拔管后3 min、拔管后5 min时的HR、SpO2、SBP、DBP与拔管前相比,差异无统计学意义(P均>0.05),而对照组对应各时段的HR、SpO2、SBP、DBP与拔管前相比显著增高,差异有统计学意义(P均<0.05)。观察组拔管即刻、拔管后1 min、拔管后3 min、拔管后5 min时的HR、SBP、DBP与对应时段对照组相比,差异有统计学意义(P均<0.05);观察组自主呼吸恢复时间、拔管时间以及清醒时间数据与对照组相比差异无统计学意义(P>0.05);观察组不良反应发生率(4.17%)显著低于对照组(16.67%),数据对比差异具有统计学意义(P<0.05)。结论:小剂量瑞芬太尼可有效缓解全身麻醉后围拔管期心血管反应,临床效果显著,无明显不良反应,值得临床广泛推广。
Objective To study the clinical effect of small dose remifentanil inhibit tracheal extubation after general anesthesia in the cardiovascular response. Method 240 patients underwent emergency operation were randomly divided into observation group and control group,each group 120 cases,the two groups were given the induction and maintenance of anesthesia,the observation group of continuous infusion of small dose remifentanil induced postoperative,saline was injected in the control group,among the two groups each patient extubation period hemodynamics,anesthesia recovery index and adverse reaction were compared. Results In the observation group,extubation time,1min after extubation,3 min after extubation,after extubation 5 min,HR,SpO2,SBP,DBP and extubation compared to before,there was no significant difference（ P〉0. 05）,while the control group compare to before extubation,the values of each time HR,SpO2,SBP,DBP were increased significantly,the difference was statistically significant（ P〈0. 05）. In the observation group extubation time,1min after extubation,3min after extubation,5min after extubation time,SBP HR,DBP and the corresponding period compared with the control group,the difference was significant（ P〈0. 05）; in the observation group spontaneous breathing recovery time,extubation time and awake time data compared with the control group the difference,wasn＇t statistically significant（ P〉0. 05）; the observation group the incidence of adverse reactions（ 4. 17%） was significantly lower than that of the control group（ 16. 67%）,the difference was statistically significant（ P〈0. 05）. Conclusion A small dose of remifentanil can effectively relieve the cardiovascular response during general anesthesia tube pull rear wall,a significant clinical effect,no significant adverse reactions,and worthy of extensive promotion.
出处
《吉林医学》
CAS
2014年第33期7335-7337,共3页
Jilin Medical Journal
关键词
瑞芬太尼
全身麻醉
气管拔管
心血管反应
临床效果
Remifentanil
General anesthesia
Tracheal extubation
Cardiovascular response
Clinical effect
