摘要
目的检测寻常型白癜风患者外周血清中趋化因子9(CXCL9)表达水平并探讨其临床意义。方法采用ELISA法检测35例寻常型白癜风患者(进展期20例,稳定期15例)和20例健康对照者血清CXCL9及IL-22含量。比较CXCL9、IL-22在各组血清中含量的差异,分析CXCL9、IL-22与白瘫风患者年龄、病程及皮损面积的相关性。结果经统计学分析,进展期白癜风患者和稳定期白癜风患者血清CXCL9、IL-22含量明显高于对照组(P<0.05);进展期白癜风患者血清CXCL9、IL-22明显高于稳定期白癜风患者,差异有统计学意义(P<0.05)。结论 CXCL9、IL-22可能参与了白癜风的发病过程。
Objective To detect the expression level of CXCL9 and IL‐22 in peripheral blood of patients with vitiligo vulgaris and explore its role in the pathogenesis of vitiligo vulgaris .Methods The level of CXCL9 and IL‐22 in peripheral blood from 35 vit‐iligo patients （20 active cases and 15 stable cases） and 20 normal controls were measured by enzyme linked immunosorbent assay . Then ,we compared the differences in different groups and analyzed their correlation with ages ,duration ,psoriasis area and severity index （PASI） .Results The contents of CXCL9 and IL‐22 in active cases and stable cases were obviously higher than those in con‐trols respectively by statistical analysis ,there was significant difference （P〈 0 .05） .The contents of CXCL9 and IL‐22 in active ca‐ses were obvious higher than those in stable cases ,there was significant difference（P〈 0 .05） .Conclusion CXCL9 and IL‐22 may be involved in the pathogenesis of vitiligo vulgaris .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第31期4225-4226,4229,共3页
Chongqing medicine
