摘要
为考察温阳为主中药复方对肥胖大鼠糖代谢的影响,采用高脂饲料喂养12周建立肥胖大鼠模型,将造模成功的SD肥胖大鼠随机分成3组,分别为模型组、二甲双胍组、温阳复方组,并设正常对照组。连续灌胃8周,在给药第4、8周测其空腹血糖,给药8周后测口服糖耐量与肌糖原、肝糖原、糖化血红蛋白含量。结果显示,给药8周后,温阳复方组空腹血糖和糖化血红蛋白含量降低,肌糖原、肝糖原含量升高。结果表明,温阳复方能够明显纠正肥胖大鼠糖代谢紊乱,有效预防和延缓早期糖尿病的发生。
To explore the effect of Warming-Yang Compound Chinese Traditional Medicine （WY-CCTM）on glucose metabolism in obesity rats,the model of obesity rats was established by feeding high fat diet for 12 weeks.Then the selected SD rats were randomly divided into three groups：model group,metformin-trea-ted group,WY-CCTM-treated group.Besides,the normal group was established.All rats were treated by intragastic gavage for 8 weeks.The fasting blood glucose of rats was detected on 4th week and 8th week during administration.After 8 weeks＇drug administration,oral glucose tolerance test （OGTT）,muscle glycogen,liver glycogen and glycosylated hemoglobin contents were determined.After 8 weeks＇drug ad-ministration,fasting glucose and glycosylated hemoglobin contents in the rats of positive group and War-ming Yang compound group decreased,and muscle glycogen,liver glycogen contents increased.This work showed that WY-CCTM-treated group could significantly correct disorders of glucose metabolism in obesi-ty rats,and effectively prevent and delay the onset of diabetes.
出处
《动物医学进展》
CSCD
北大核心
2014年第11期66-69,共4页
Progress In Veterinary Medicine
基金
广东省科技计划项目(2011A030100016
2011B031700070)
关键词
肥胖大鼠
温阳复方
糖代谢
obesity rat
warming-yang compound
glucose metabolism
