摘要
目的比较两种不同的麻醉及镇痛方法对肺癌根治术患者细胞免疫功能的影响。方法将40例择期剖胸肺癌手术患者分为两组,分别行全凭静脉麻醉联合静脉镇痛(A组)与全麻复合硬膜外麻醉联合硬膜外镇痛(B组),比较两组患者围术期不同时点的T细胞亚群及NK细胞功能的变化。结果两组除CD8^+各指标术后均有所上升(P<0.01)外,其他细胞学指标(CD3^+,CD4^+,NK细胞)术后均有所下降(P<0.05或0.01);B组各指标在术后72h基本恢复术前水平(均P>0.05),但A组仍与术前有明显差异(P<0.05或0.01)。结论全麻复合硬膜外麻醉联合术后硬膜外镇痛是肺癌患者免疫功能干扰较小且恢复较快的一种麻醉方式。
Objective To investigate the effect of two different methods of anesthesia and analgesia on cellular immune function in patients underwent radical resection of pulmonary carcinoma. Methods Forty patients underwent elective thoraco-tomy lung cancer surgery were randomly divided into two groups. Patients were implemented either total intravenous anesthesia combined with intravenous analgesia （group A）or general anesthesia combined with epidural anesthesia and post- op- epidural analgesia （group B）. T cellsubsets and NK cellfunction were compared within 72h after surgery. Results Except for the in-crease of CD8＋ （P＆lt;0.01）, postoperative CD3^＋,CD4^＋ and NK cellwere decreased （P〈0.05 or 0.01） in both groups.The indices recovered to the pre- op level in group B 72h after surgery（P〉0.05）,but not in group A. Conclusion General anesthesia com-bined with epidural anesthesia and post- op epidural analgesia might be an effective anesthesia method with faster recovery and minor interference on the immune function of lung cancer patients.
出处
《浙江医学》
CAS
2014年第20期1674-1676,1680,共4页
Zhejiang Medical Journal
基金
浙江省自然科学基金(Y2110421)
关键词
全身麻醉
硬膜外麻醉
硬膜外镇痛
细胞免疫
General anesthesia
Epidural anesthesia
Epidural analgesia
Cellular immunity
