摘要
目的:比较单相与双相抑郁患者执行功能及下丘脑-垂体-肾上腺(HPA)轴释放功能的差异。方法:对32例单相与31例双相抑郁患者于0、4和8周进行连线测验(TMT)、彩色文字阅读测验(Stroop-C、Stroop-CW),同步测定24 h尿17-羟皮质醇、24 h尿游离皮质酮、血浆皮质醇,进行组间比较,并与28例健康者对照。结果:0和4周抑郁组的TMT-A、TMT-B、Stroop-C、Stroop-CW均显著长于对照组(P<0.01),血浆皮质醇显著高于对照组(P<0.01);0周单相组TMT-B、Stroop-C均显著长于双相组(P<0.01)。单相组和双相组0周血浆皮质醇低谷浓度不出现于12:00 AM,午夜低谷现象消失,至4周午夜分泌低谷现象恢复。结论:在执行功能和HPA轴释放功能方面,单相与双相抑郁存在差异,需加以关注。
Objective To compare the executive functions and releases function of hypothalamus-pituitaruadrenal （HPA） axis in patients with single and bipolar depression disorder. Methods 32 single-phase depression （the single group） and 31 bipolar depression patients （the bipolar group） were enrolled in this study. The trail making test A and B and Stroop test （Stroop-C and Stroop-CW） were tested at 0,4 week and 8 week later. In addition, levels of 24-h urine 17-OH cortisol, 24-h urine free corticosterone and plasma cortisol were also detrmined. The related results were compared among the two groups and 28 healthycontrol group. Results The TMT-A, TMT- B,Stroop-C and Stroop-CW of the baseline and at 4 week were significantly longer in the depression group than those in the control group （P 〈 0.01, respectively）, and the plasma cortisol was also higher in the depression group than that in the control （P 〈 0.01 ）. On baseline, the single group showed significantly longer TMT-B and Stroop-C than those in the bipolar group （P 〈 0.01, respectively）. At 0 week, lower plasma cortisol concentrations did not appear at 12.00 AM, and the midnight deep valley secretion disappeared. However, the midnight deep valley secretion recoveried at 4 week. Conclussion The differences on executive dysfunction and excessive release of HPA-axis function between the single and the bipolar depression should be followed with interest.
出处
《实用医学杂志》
CAS
北大核心
2014年第22期3576-3578,共3页
The Journal of Practical Medicine
基金
广东省医学科研基金项目(编号:A2009648)
关键词
抑郁障碍
单相/双相抑郁
执行功能
HPA轴
Depression disorder
Single/loipolardepression
Executivefunction
Hypothalamus-pituitary- adrenal axis
