摘要
目的探讨重症肺炎患儿危重症评分与凝血指标的关系。方法选择2011年8月至2013年3月期间,河北省唐山市丰润区人民医院重症监护室收治的重症肺炎患儿共160例作为实验组,同期选择60例门诊体检健康儿童作为对照组,分析两组患者数据进行分析。结果实验组可溶性P选择素、D-二聚体均较对照组高,血小板计数较对照组低,差异具有统计学意义(t_(可溶性P选择素)=10.52,t_(D-二聚体)=5.03,t_(血小板计数)=11.66,均P<0.05);而活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fib)经比较差异无统计学意义(t_(APTT)=0.87,t_(PT)=1.05,t_(Fib)=0.72,均P>0.05)。随着病情程度加重,可溶性P选择素、D-二聚体均较前升高,血小板计数较前降低,组间比较差异具有统计学意义(F_(可溶性P选择素)=50.45,F_(D-二聚体)=50.88,F_(血小板计数)=24.49,均P<0.05),APTT、PT无明显变化,差异无统计学意义(F_(APTT)=0.61,F_(PT)=0.77,F_(Fib),=0.66,均P>0.05)。可溶性P选择素和D-二聚体与疾病危重程度呈现正相关,血小板计数与疾病危重程度呈现负相关。结论重症肺炎患儿容易出现凝血机制异常,可溶性P选择素、D-二聚体和血小板计数与疾病危重程度密切相关,指导临床治疗。
Objective To investigate the relationship between pediatric critical illness scores （ PCIS ） of severe pneumonia and blood coagulation index.Methods From August 2011 to March 2013 there were 160 cases of severe pneumonia treated in ICU of Fengrun District People’ s Hospital of Tangshan.They were recruited in experimental group.At the same period 60 healthy out-patient children undergoing physical examination in the hospital were selected in the control group.The data of two groups were analyzed.Results Compared with the control group, the experimental group had higher levels of soluble P selectin and D-two dimer but lower platelet count, and the differences were statistically significant （tsoluble P selectin =10.52, tD-two dimer =5.03, tplatelet count =11.66, all P〈0.05）.However, there were no significant differences in activated partial thromboplastin time （APTT）, prothrombin time （PT） and Fib （tAPTT =0.87, tPT =1.05, tFib =0.72, all P〉0.05）.As the disease aggravated, the levels of soluble P selectin and D-two dimer increased, but the platelet count decreased.Group comparison showed significant difference （Fsoluble P selectin =50.45, FD-two dimer =50.88, Fplatelet count =24.49, all P〈0.05）.APTT and PT did not change significantly （FAPTT =0.61, FPT =0.77,FFib =0.66, all P 〉0.05）.Soluble P selectin and D-two dimmer levels were positively correlated with the severity of illness, but the platelet count was negatively related with it.Conclusion Children with severe pneumonia are easy to suffer abnormal clotting mechanisms.Soluble P selectin, D-two dimer and platelet count and are closely related with the severity of illness.
出处
《中国妇幼健康研究》
2014年第5期786-787,792,共3页
Chinese Journal of Woman and Child Health Research
关键词
重症肺炎
危重症评分
凝血指标
相关性
severe pneumonia critical illness score coagulation index correlation
