摘要
目的分析大剂量奥美拉唑治疗老年胃溃疡合并出血的疗效。方法选择2009年6月—2012年6月收治的78例老年胃溃疡合并出血患者作为研究对象,随机分成对照组和观察组各39例。两组患者均给予常规对症治疗。对照组给予奥美拉唑40 mg加入生理盐水100 ml静脉滴注,12 h/次。观察组给予大剂量奥美拉唑首次80 mg静脉推注,随后给予8 mg/h的静脉滴注。两组治疗3 d后,均改为奥美拉唑肠溶片口服,1次/d,20 mg/次,1个月为1个疗程。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果治疗后观察组患者≤3 d、4~30 d、31 d^3个月的再次出血率(7.69%、0、0)明显低于对照组(20.51%、5.13%、2.56%)(P<0.05)。观察组总有效率为94.87%,对照组为76.92%,比较差异有统计学意义(P<0.05)。结论采用大剂量奥美拉唑治疗老年胃溃疡合并出血患者,能有效提高患者的临床治疗效果,同时降低了再出血的风险,适合在临床推广应用。
Objective To analyze the clinical efficacy of high - dose omeprazole in treating 78 senile cases of gastric ulcer with hemorrhage. Methods From Jun. 2009 to Jun. 2012, 78 elderly cases of ulcer with hemorrhage treated in our hospital were selected and randomly divided into observation group and control group, 39 cases for each group. Both group received conventional therapy. Control group received omeprazole, 40 mg for intravenous administration, 12 hourly. Observation group received high - dose omeprazol, 80 mg for initial intravenous injection, then for intravenous administration at the speed of 8 mg/h. Both groups were treated for 3days and received oral omeprazole,20 rag, once daily. The treatment course lasted I month. Measurement dath were processed by t - test, count data by x^2 test, the result of P 〈 0. 05 was considered statistically significant. Results After treatment, the rate or re - bleeding was 7.69%, 0 and 0 respectively within 3days, during 4 -30 d and during 31 d - 3m in observation group, which was significantly lower than that in control group （20.51% ,5.13% ,2.56% ） （ P 〈 0.05 ）. The total effective rate was 94.87% in observation group and 6.92% in the controls, the difference was statistically significant （ P 〈 0.05 ）. Conclusions High - dose omeprazole for gastric ulcer with bleeding in the elderly can effectively improve the chnical efficacy, and reduce the risk of re - bleeding, which is suitable for clinical application.
出处
《社区医学杂志》
2014年第22期24-25,共2页
Journal Of Community Medicine
关键词
奥美拉唑
胃溃疡
出血
Omeprazole
Gastric ulcer
Bleeding
