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颅脑外伤后进展性出血性损伤与血浆D-二聚体浓度的相关分析 被引量:3

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摘要 目的揭示血浆D-二聚体浓度对颅脑外伤后进展性出血性损伤的预测价值。方法本研究选取2010年8月至2012年8月,本院收治的颅脑外伤患者和同期健康体检者各168例,采用免疫比浊法测定血浆D-二聚体浓度,采用多因素Logistic回归和ROC曲线分析血浆D-二聚体浓度与进展性出血性损伤的关系。结果行t检验,颅脑外伤患者血浆D-二聚体浓度(1.74±0.85)mg/L较对照组(0.16±0.05)mg/L显著升高(P〈0.001)。45例(26.8%)颅脑外伤患者发生进展性出血性损伤。行t检验,进展性出血性损伤患者血浆D-二聚体浓度(2.62±0.72)mg/L较非进展性出血性损伤患者(1.36±0.67)mg/L显著升高(P〈0.001)。Logistic回归分析显示,血浆D-二聚体浓度(OR=1.220,95%CI=1.109-2.408,P〈0.001)是进展性出血性损伤发生的独立危险因素。ROC曲线分析显示,血浆D-二聚体浓度对进展性出血性损伤发生有显著预测价值(曲线下面积=0.848,95%CI=0.784-0.907,P〈0.001),且判定血浆D-二聚体浓度大于2.17 mg/L,对预测进展性出血性损伤发生有84.4%的灵敏度和73.2%的特异度。结论血浆D-二聚体浓度与颅脑外伤后进展性出血性损伤的发生密切相关,且具有较高的临床预测价值和指导意义。
出处 《浙江创伤外科》 2014年第5期773-774,共2页 Zhejiang Journal of Traumatic Surgery
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参考文献8

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二级参考文献12

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