摘要
目的探讨NES1基因在结肠癌细胞中表达及意义。方法用RT-PCR方法检测NES1mRNA在正常结肠细胞、结肠癌细胞株HT29、HCT116表达情况。结果 NES1在结肠癌细胞株中表达较正常结肠黏膜细胞明显增高。结论 NES1基因在结肠癌的发生发展中起重要作用,这为选用NES1作为结肠癌治疗靶点提供了实验依据及理论基础。
Objective To investigate the expression of NES1 in colon carcinoma cells and its significance. Methods The ex-pression of NES1mRNA in clon carcinoma cells and human colon cell was detected by RT-PCR technique. Results The expres-sion of NES1mRNA in colon carcinoma cell lines HT29 and HCT116 was significantly higher （P〈0.05）. Conclusion NES1 may play an important role of occurrence and development of colon carcinoma.
出处
《江西医药》
CAS
2014年第10期994-995,998,共3页
Jiangxi Medical Journal
