摘要
目的从剂量学探讨减小非小细胞肺癌三维适形放射治疗照射体积的可行性。方法32例非小细胞肺癌患者均做2个放射治疗计划：常规照射野三维适形放射治疗计划和小野三维适形放射治疗计划，用剂量体积直方图评估肿瘤靶区剂量和正常组织受照剂量。结果小野三维适形放射治疗仍能满足肿瘤靶区剂量的要求，亚临床灶的最小剂量、最大剂量和平均剂量分别为50．93Gy、54．60Gy和（52．37±1．02）Gy。与常规适形野相比，小野适形放疗减少了患侧肺、脊髓和食管的平均剂量（P〈0．05）。结论缩小非小细胞肺癌三维适形放射治疗照射野能满足肿瘤靶区剂量的需要，同时降低了正常组织的受照剂量，可在临床开展相关研究。
Objective To investigate the dosimetry and feasibility of target volume reduction in three-dimensional conformal radiotherapy for non-small cell lung cancer（NSCLC）. Methods Two differ- ent radiation treatment planning, the conventional conformal planning and the small volume conformal plan- ning,were designed for 32 NSCLC patients. Dose-olume histograms were used to assess the dosimetric dis- parity in target regions and surrounding organs at risk. Results Small volume conformal planning could meet the demand of target dose. The least dose, the maximum dose, and the mean dose at subclinical targets were 50.93 Gy,54.60 Gy and（52.37 ± 1.02） Gy,respectively. Comparing with the conventional conformal planning, small volume conformal planning reduced the mean dose of tung, spinal cord and esophagus（P 〈 0.05）. Conclusion Small volume conformal planning can meet the dosimetric requirement of target vol- ume for NSCLC and reduce the dose of normal tissues, which is worthy of further clinical study.
出处
《临床外科杂志》
2014年第9期692-694,共3页
Journal of Clinical Surgery
基金
湖北省自然科学基金重点项目（编号：2013CFA006）
关键词
非小细胞肺癌
三维适形放射治疗
靶体积
non-mall cell lung cancer
three-dimensional conformal radiotherapy
target volume
