摘要
目的：探讨体外受精（IVF）或卵泡浆内单精子注射（ICSI）周期中的子宫内膜异位症（EMS）患者临床结局的影响因素。方法：回顾性分析了2011年1月~2013年3月在北京大学深圳医院生殖医学科接受IVF或（和）ICSI治疗的321例患者,将其分为EMS组（143例）和排除EMS的对照组（178例）,根据妊娠结局再将两组分为妊娠组和未妊娠组,对异位症组和对照组的妊娠和未妊娠组临床资料进行总结。结果：1EMS患者妊娠组与未妊娠组相比,基础窦卵泡数增多,Gn用量减少,而h CG日E2水平、获卵数、移植及冷冻胚胎数均增加,有统计学差异（P〈0.05）。对照组的妊娠组与未妊娠组的上述指标均无统计学差异（P〉0.05）;EMS患者妊娠组与未妊娠组相比,体重指数（BMI）升高,有统计学差异〔（20.72±2.41）kg/m2vs（19.86±1.96）kg/m2,P〈0.05〕。对照组的妊娠组与未妊娠组的BMI无统计学差异〔（21.33±2.52）kg/m2vs（21.39±2.99）kg/m2,P〉0.05〕。2EMS妊娠组与对照组妊娠组的窦卵泡数、Gn用量、h CG日E2水平、获卵数、移植胚胎数、冷冻胚胎数、BMI差异无统计学意义（P〉0.05）。3EMS未妊娠组与对照组未妊娠组相比冷冻胚胎数减少,BMI下降,余指标差异均无统计学意义（P〉0.05）。结论：IVF助孕成功妊娠的EMS患者卵巢反应性较好,BMI较高,EMS患者的卵巢反应性是影响患者助孕结局的重要因素。
Objective： To explore the influencing factors of pregnancy outcome during in vitro fertilization （IVF） or intracytoplas- mic sperm injection （ICSI） cycles in patients with endometriosis. Methods： A total of 321 patients receiving IVF and （or） ICSI in department of reproductive medicine in Shenzhen Hospital of Beijing University from January 2011 to March 2013 were analyzed retrospectively, then the patients were divided into endometriosis group （143 patients） and control group （ 178 patients） ; the patients in endometriosis group and control group were further divided into pregnancy subgroup and non - pregnancy subgroup ; the clinical data in different groups were summarized. Results： In endometriosis group, compared with non - pregnancy subgroup, antral follicle count in pregnancy subgroup increased, the dosage of Gn decreased, estradiol level on the day of human chorionic gonadotropin （hCG） injection, the number of retrieved oocytes, the number of embryos transferred and the number of frozen embryos increased, there were statistically significant differences （ P 〈 0.05 ） . In control group, there was no statistically significant difference in the indexes above - mentioned between pregnancy subgroup and non - pregnancy subgroup （P 〉 0. 05 ） ; in endometriosis group, the values of body mass index （BMI） in pregnancy subgroup and non -pregnancy subgroup were （20. 72 ± 2. 41 ） kg/m2 and （ 19.86 ± 1.96） kg/m2, respectively, there was statistically significant difference （P 〈 0.05 ） . In control group, the values of BMI in pregnancy subgroup and non - pregnancy subgroup were （ 21.33 ± 2. 52） kg/m2 and （21.39 ±2. 99） kg/m2 , respectively, there was no statistically significant difference （P 〉 0. 05 ） . There was no statistically significant difference in antral follicle count, the dosage of Gn, estradiol level on the day of hCG injection, the number of retrieved oocytes, the number of embryos transferred, the number of frozen embryos and BMI between pregnancy subgroup in endometriosis group and pregnancy subgroup in control group （ P 〉 0. 05 ）. The number of frozen embryos and BMI in non - pregnancy subgroup in endometriosis group were significantly lower than those in non - pregnancy subgroup in control group, but there was no statistically significant difference in the other indexes （ P 〉 0. 05 ）. Conclusion： The patients with endometriosis who succeed in IVF and get pregnancy have good ovary response and high BMI. Ovary response is an important influencing factor of IVF outcome.
出处
《中国妇幼保健》
CAS
北大核心
2014年第33期5458-5461,共4页
Maternal and Child Health Care of China
基金
2013年深圳市科技计划项目〔201303031〕
关键词
EMS
体外受精-胚胎移植
卵巢反应性
体重指数
Endometriosis
In vitro fertilization and embryo transfer
Ovary response
Body mass index
