摘要
通过喷雾干燥技术分别制备乳糖-糊化淀粉、乳糖-不糊化淀粉共处理辅料,比较共处理辅料与物理混合物及喷雾干燥乳糖之间在粉体学性质和所形成片剂性质上的差异,并以栀子提取物和垂盆草提取物为模型药物,考察共处理辅料在中药直接压片中应用的可行性。结果表明,将淀粉预糊化后再与乳糖共喷雾干燥可提升淀粉作为黏合剂的性能与效率,制备所得共处理辅料的物理机械性质得到显著改善。在中药粉体直接压片中,该共处理辅料表现出比自制和市售喷雾干燥乳糖更好的可压性和更大的载药量。综上所述,乳糖-糊化淀粉共处理辅料具有优良的物理机械性质,有望成为一种新型的直压共处理辅料。
Co-processed excipients with gelatinized or non-gelatinized starch were prepared by spray drying. Powder and tablet properties of co-processed excipients prepared were compared with those of physical mixtures and spray-dried lactose. Their applicability in traditional Chinese medicine（ TCM） powder tableting was tested on two TCM extracts,i. e.,the gardenia extract and the Herba Sedi extract. It was shown that gelatinizing starch before co-spray drying with lactose could improve the performance and efficiency of starch as a binder,resulting in remarkable improvement in physicomechanical properties of co-processed excipients prepared. Compared to self-made and commercially available spray-dried lactose,co-processed excipients achieved better compactability and higher drug loading for TCM extracts. In conclusion,the lactose-gelatinized starch co-processed excipient,with excellent physicomechanical properties,is promising to be explored as a new excipient for direct tableting.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第22期4329-4334,共6页
China Journal of Chinese Materia Medica
基金
上海市教育委员会科研创新项目(13ZZ098)
关键词
共处理辅料
喷雾干燥
乳糖
糊化淀粉
压片
co-processed excipient
spray drying
lactose
gelatinized starch
tableting
