摘要
目的：建立雷公藤粘胶分散型贴剂的质量标准。方法：采用薄层色谱（TLC）法对贴剂中有效成分雷公藤甲素进行鉴别;采用高效液相色谱法对雷公藤甲素进行含量测定。结果：TLC斑点清晰,分离度较好;雷公藤甲素浓度在0.5~10μg/mL范围内与峰面积积分值呈良好线性关系,r=0.9999（n=7）,平均加样回收率为100.97%,RSD=1.64%（n=9）。结论：所建标准可用于雷公藤粘胶分散型贴剂的质量控制。
Objective： To establish the quality standard for Tripterygium wilfordii drug- in- adhesive patch. Methods： Triptolide, which acted as the main effective component of the patch, was identified by TLC and its content in the patch was determined by HPLC. Results ： The TLC spots were clear and well - separated. The linear range of triptolide in the patch was 0.5 - 10μg/mL （ r = 0. 9999, n = 7 ） with the average recovery of 100.91% （ RSD = 1.40% , n = 9 ）. Conclusion ： The method is feasible for the quality control of Tripterygium wilfordii drug - in - adhesive patch.
出处
《江西中医药大学学报》
2014年第5期57-59,共3页
Journal of Jiangxi University of Chinese Medicine
基金
江西省卫生厅中医药科研计划项目(2011Z0037)
