摘要
目的 了解重症医学科收治的中毒性表皮坏死松解型药疹患者的临床特征，为今后重症科医生和护士对该类患者尽早进行干预治疗和护理提供参考依据。方法 收集本院重症医学科2009年3月-2014年3月收治的q-毒性表皮坏死松解型药疹患者的临床资料，对其一般资料，如人口学数据、年龄、性别、职业、潜伏期、过敏史、可疑致敏药物、护理及治疗方法和转归等进行回顾性分析。结果 13例中毒性表皮坏死松解型药疹患者8例有既往史，别嘌醇所致药疹平均潜伏期明显较其他药物长，平均为13±7．6d。皮疹均为全身分布不规则的红斑及松弛性水疱或大疱且有不同程度的黏膜受累症状，实验室检查结果异常多。13例患者的住院时间为1—43d，平均17．31d。结论 重症医学科的中毒性表皮坏死松解型药疹患者病情更凶险，病死率极高，针对病因尽早进行规范治疗和严格护理是决定患者预后与转归的关键N素。
Objective To summarize the clinical features of toxic epidermal necrolysis-type drug eruption in the department of critical care medicine, which could serve as a future reference for critical care professionals to im- prove patient care. Methods To summarize the clinical features of toxic epidermal necrolysis-type drug eruption in the department of critical care medicine, which could serve as a future reference for critical care professionals to improve patient care. Results 8 out of 13 patients had a past history of toxic epidermal necrolysis-type drug eruption. The average incubation period for allopurinol was 13 ＋ 7.6d,which was longer than other drugs. Skin lesions included generalized irregular erythemas,flaccid blisters and bullae with certain extent of mucosal involvement. Laboratory test results were abnormal. The hospitalization time varied from 1 d to 43d,with an average of 17.31 d. Conclusion In critical care medicine, patients with severe toxic epidermal necrolysis-type drug eruption have a higher fatality rate. Early pathogenesis-based treatment and appropriate care are key determinants for the prognosis and outcome of these patients.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第11期1133-1134,1160,共3页
The Chinese Journal of Dermatovenereology
关键词
药疹
中毒性表皮坏死松解型
临床分析
重症医学
Drug eruption, toxic epidermal necrolysis-type
Clinical analysis
Intensive medical
