摘要
乳腺癌转移抑制基因1(BRMS1)是一个有活性的肿瘤转移抑制基因,参与抑制乳腺癌、黑素瘤、鼻咽癌、非小细胞肺癌、卵巢癌等恶性肿瘤的转移。BRMS1编码蛋白主要通过转录调控转移相关靶基因,参与调节细胞凋亡、细胞通讯、肿瘤血管新生等多种细胞事件。从BRMS1基因的分子结构、表达调控、生物学功能以及转移抑制机理等方面对BRMS1的研究进展做简要回顾。
Breast cancer metastasis suppressor 1 （BRMS1） has been demonstrated to be an active metastasis suppressor gene, showing metastasis suppressive role in breast cancer, melanoma, nasopharyngeal carcinoma, nonsmall cell lung cancer, ovarian cancer, and etc. It has been revealed that BRMS1 protein is able to transcriptionally regulate metastasis-related genes, further to regulate multiple cell events including cell apoptosis, cell communication, tumor angiogenesis, and etc. Herein, the molecular structure, expressional regulation, biological function and metastasis suppression mechanism ofBRMSI gene are briefly reviewed.
出处
《生命科学》
CSCD
2014年第10期1057-1066,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金青年科学基金项目(31000558)
上海市教委"晨光"计划(2012年)
关键词
乳腺癌转移抑制基因1
肿瘤转移
转录调控
细胞凋亡
细胞通讯
肿瘤血管新生
breast cancer metastasis suppressor 1
tumor metastasis
transcriptional regulation
cell apoptosis
cell communication
tumor angiogenesis
