摘要
目的:研究黄芪与防己"药对"对自发性高血压大鼠早期肾损害的保护作用。方法:16周龄的雄性自发性高血压大鼠(SHR)16只,随机分为4组,即模型组、药对组、依那普利组、药对+依那普利组,SD大鼠4只为正常血压组,灌胃4周后,观察"药对"对自发性高血压大鼠血压水平及尿微量白蛋白的影响。结果:药对组、依那普利组、药对+依那普利组与同期模型组比较,血压、随机尿微量白蛋白、肾脏指数下降显著(P<0.05),与依那普利组作用结果相似,3组间用药4周后比较肾脏指数无显著差异(P>0.05)。结论:黄芪与防己药对有降压作用,且对自发性高血压大鼠早期肾损害有保护作用。
Objective ： To investigate the protective effect of Menispermaceae and Astragalus. Methods ： The sixteen SH rats were randomly divided into control group, Menispermaeeae and Astragalus group, enalapril group and mix group. Four SD rats were divided into normahensive group. The blood pressure, microalbuminuria and renal indices were measured after four weeks. Restllts ： The blood pressure, microalbuminnria and renal indices in Menispermaceae and Astragalus group, enalapril group and mix group were obviously less than that in control group （ P〈0.05 ）. Conclusion ： B Menispermaceae and Astragalus could obviously protect early renal damage in spontaneous hypertensive rats.
出处
《辽宁中医药大学学报》
CAS
2014年第10期52-53,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
黄芪
防己
高血压早期肾损害
自发性高血压大鼠
Astragalus
Menispermaceae
early renal damage with essential hypertension
spontaneous hypertensive rats
