摘要
目的:研究连续性血液净化补充氨基酸对多器官功能障碍综合征(MODS)患者营养状态和免疫功能的影响。方法:将本院ICU收治的60例MODS患者纳入研究,给予连续性血液净化治疗,根据营养支持方案不同分为两组,观察组给予氨基酸、葡萄糖、脂肪乳的营养方案、对照组给予不含氨基酸的营养方案,比较两组的血清氨基酸谱、蛋白含量、人体测量学指标、免疫功能。结果:观察组的血清赖氨酸、苯丙氨酸、甲硫氨酸、苏氨酸、异亮氨酸、亮氨酸、缬氨酸、白蛋白、前蛋白含量以及上臂肱三头肌皮褶厚度、上臂围、上臂肌围、CD4+T细胞比例、IgA、IgG、IgM含量高于对照组,CD8+T细胞比例低于对照组。结论:连续性血液净化补充氨基酸有助于增加血清游离氨基酸和蛋白水平、改善细胞免疫和体液免疫功能,是MODS患者连续性血液净化时理想的营养支持方法。
Objective; To study the effects of continuous blood purification and amino acid supplementation on nutritional status and immune function of MODS patients. Methods： 60 cases of MODS admitted from 2011 May to 2014 May were enrolled and given continuous blood purification treatment. Patients were divided into two groups according to different nutrition support schemes. Patients in observation group were given amino acid, glucose, fat milk nutrition plan, while patients in control group were given nutrition programs without amino acid. Then serum amino acid spectrum, protein content, anthropometric indexes, immune functions were compared. Results： Serum lysine, phenylalanine, methionine, threonine, isoleucine, leucine, valine, albumin, prealbumin content and triceps skin fold, upper arm circumference, upper arm muscle circumference, CD4＋T cells proportion, IgA, IgG, IgM levels of observation group were higher than those of control group; CD8＋ T cells proportion was lower than that of control group. Conclusions： Continuous blood purification amino acid supplementation contributes to increase serum free amino acid and protein levels, improve cell immunity and humoralimmune function. It＇s an ideal nutritional support method for MODS patients with continuous blood purification.
出处
《海南医学院学报》
CAS
2014年第11期1518-1520,1523,共4页
Journal of Hainan Medical University
基金
张家口市科学技术和地震局
张家口市科学技术研究与发展计划社发领域处筹项目(113461-5-3)~~
