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粒细胞巨噬细胞集落刺激因子调控树突状细胞发育和功能的研究进展 被引量:1

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摘要 树突状细胞(DC)是重要的抗原提呈细胞,专门负责抗原捕获、加工并提呈给下游T淋巴细胞从而诱导免疫应答或者免疫耐受。维持DC亚群在体内的动态平衡是保证机体免疫系统正常运转的基础。无论机体处于炎症或静息状态,粒细胞巨噬细胞集落刺激因子(GM-CSF)对DC亚群发育、分布、功能及维持DC亚群动态平衡均具有重要的调控作用。本文主要综述了GM-CSF对DC亚群发育与功能的调控作用。阐明DC发育与功能的调控机制,有助于开发新的基于DC的免疫治疗方案。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第10期1106-1109,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(30760136)
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  • 1Banehereau J, Steinman RM. Dendritic cells and the control of immunity[J]. Nature, 1998, 392(6673) : 245 -252.
  • 2Hung CH, Yang SN, Wang YF, et al. Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells [J/OA]. PLoS One, 2013, 8(9) : e73534.
  • 3van de Laar L, Coffer PJ, Woltman AM. Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy [ J]. Blood, 2012, 119 ( 15 ) : 3383 - 3393.
  • 4Francisco-Cruz A, Aguilar-Santelises M, Ramos-Espinosa O, et al. Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor[ J/OL]. Med Oncol, 2014, 31 (1): 774.
  • 5Steimnan RM. Dendritic cells and the control of imnmity: enhancing the efficiency of antigen presentation [ J]. Mt Sinai J Med, 2001, 68(3) : 160 -166.
  • 6Pal I, JD. The role d the lymphatic systen in vaccine treking and immune response [ J ]. Adv Drug Deliv Rev, 2011, 63 ( 10/11 ) : 909 - 922.
  • 7Haj AR, Sadrai Z, Lee IlK, et al. Expression d the chen'kine decoy receptar D6 mediates dendritic cell function and promotes corneal allograft rejection[ J]. Mol Vis, 2013, 19 : 2517 - 2525.
  • 8Mikhak Z, Strassner JP, Luster AD. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4[J]. J Exp Med, 2013, 210(9) : 1855 - 1869.
  • 9Kling JC, Darby J, Kfirner H. CCR7 facilitates the pro-inflammatory function of dendritic cells in experimental leishmaniasis[ J ]. Parasite Immund, 2014, 36(4): 177-185.
  • 10Brire F, Bendriss-Vermare N, Delale T, et al. Origin and filiation of human plasmacytoid dendritic cells [ J ]. Hum Immunol, 2002, 63(12) : 1081 -1093.

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