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氟西汀治疗形觉剥夺性弱视猫的视觉电生理研究

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摘要 目的研究新生猫制作形觉剥夺性弱视模型,采用图形视觉诱发电位检测氟西汀治疗前后的弱视猫,了解特征峰潜伏期和波幅的变化,进而观察氟西汀治疗形觉剥夺弱视猫的效果。方法采用德国Roland视觉电生理仪,对3例正常对照组猫和15例形觉剥夺性弱视猫建模12周,喂养氟西汀后4、8、12、16、20周进行图形视觉诱发电位的检测,对特征峰进行潜伏期和波幅的比较。结果正常对照组P波的潜伏期(48.33±3.51)ms,波幅(55.69±3.52)nV,单眼形觉剥夺猫P波的潜伏期(58.23±4.62)ms,波幅(38.24±2.96)nV,与正常对照组相比差异有统计学意义(P<0.05)。氟西汀治疗4、8周时,P波的潜伏期较治疗前稍缩短,波幅稍增加,与氟西汀治疗前之间差异无统计学意义。治疗12、16、20周时,P波的潜伏期缩短,波幅增加,与氟西汀治疗前的形觉剥夺猫之间差异有统计学意义。结论氟西汀治疗形觉剥夺弱视猫能使其视觉电生理P波的潜伏期缩短,波幅增加,其变化过程类同于人类儿童弱视治愈过程中视觉电生理P波的潜伏期和波幅的变化趋势。
出处 《广东医学》 CAS CSCD 北大核心 2014年第17期2673-2675,共3页 Guangdong Medical Journal
基金 江西省科技计划项目(编号:2010BSB00207)
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