摘要
急性T淋巴细胞白血病(acute T lymphocyte leukemia,T-ALL)是一种特殊类型的淋巴细胞恶性增殖性疾病,以外周血高白细胞计数、原始细胞比例升高为主要特征,易发生胸膜渗出、中枢神经系统浸润及纵隔肿瘤,病情较凶险、进展快、预后欠佳。近年来T-ALL在我国的发病率有增高的趋势。该文主要介绍了免疫表型与预后,初始化治疗、挽救治疗、造血干细胞移植、新药治疗等方面对T-ALL的诊治新进展。
Acute T lymphocyte leukemia（T-ALL） is a special kind of lymphocytes malignant hyperplastie disease. Its key feature is high peripheral blood leukocyte count, and high proportion of the original cells. Cells pleural effusion, central nervous system infiltration and the mediastinum tumor often occurred. The disease is featured with high danger, fast progress, and poor prognosis. In recent years, the incidence of T-ALL has shown an increase trend in our country. Here is mainly to introduce the recent progress in the diagnosis and treatment of T-ALL from the perspectives of immune phenotype and prognosis, initial treatment, salvage therapy, hematopoietic stem cell transplantation and new druz treatment.
出处
《医学综述》
2014年第17期3148-3150,共3页
Medical Recapitulate
基金
广西自然科学基金资助(2012GXNSFAA053112)
广西自筹经费科研课题
桂林市科技攻关项目(Z20110119-1-12)
关键词
T淋巴细胞白血病
急性
靶向治疗
造血干细胞移植
诊断
T lymphocyte leukemia, acute
Targeted treatment
Hematopoietic stem cell transplantation
Diagnosis
