摘要
目的：探讨乙型肝炎病毒（HBV）前S1（PreS1）抗原及抗体检测的临床应用价值。方法于2013年3～11月，随机选择具有不同乙型病毒性肝炎（简称乙肝）两对半检测结果的患者120例进行PreS1抗原及抗体检测，分析PreS1抗原及抗体检测结果与两对半检测结果的关系。结果大三阳及小三阳患者 PreS1抗原阳性检出率为89％和7％，乙肝表面抗原（HBsAg）、乙肝核心抗体（HBcAb）阳性患者阳性检出率为14％，单纯 HBsAg阳性患者阳性检出率为5％。PreS1抗原与 HBsAg、乙肝 e抗原和 HBcAb具有一定的相关性。结论两对半联合PreS1抗原、抗体检测能够更灵敏、准确地反映乙肝患者的病情和预后，在HBV感染早期诊断方面也具有一定的临床应用价值。
Objective To explore the clinical significance of hepatitis B virus （HBV） PreS1 antigen and anti-body detection .Methods During Mar .and Nov .2013 ,PreS1 antigen and antibody were detected in 120 patients with different detected results of hepatitis type B serum markers ,hepatitis B surface antigen and antibody （HBsAg ,HB-sAb） ,hepatitis Be antigen and antibody （HBeAg ,HBeAb） ,and hepatitis B center antibody （HBcAb） .Correlation between PreS1 antigen and antibody with serum markers were analyzed .Results Positive rate of PreS1 antigen in pa-tients with positive HBsAg ,HBeAg and HBcAb was 89% ,in patients with positive HBsAg ,HBeAb and HBcAb was 7% ,in patients with positive HBsAg and HBcAb was 14% ,and in patients with positive HBsAg was 5% .PreS1 an-tigen might be correlated with HBsAg ,HBeAg and HBcAb .Conclusion Combined detection of serum markers of HBV ,PreS1 antigen and antibody might be more sensitive and exact to reflect disease condition and prognosis of pa-tients with hepatitis type B ,which might be also with clinical significance for the early diagnosis of HBV infection .
出处
《检验医学与临床》
CAS
2014年第17期2406-2407,共2页
Laboratory Medicine and Clinic
