摘要
本文探索了介入瓣瓣膜膜片的制备方法和瓣膜化学改性和切割方法对瓣膜膜片拉伸性能和缝合力力学性能的影响。本研究通过采集新鲜猪心包材料并应用碳化亚胺溶液和戊二醛溶液作为固定液的方法合成介入瓣瓣膜膜片材料;通过茚三酮法检测瓣膜膜片材料的交联度情况;应用拉伸及缝合力力学实验测试介入瓣瓣膜膜片材料的生物力学性能;通过场发射扫描电镜表征瓣膜膜片材料在经过缝合线拉伸作用后的胶原纤维取向分布。结果表明:经过化学改性后,介入瓣瓣膜膜片材料的交联度达到93.78%±3.2%;瓣膜膜片材料的拉伸强度达到(8.24±0.79)MPa;缝合力强度增加了102%。介入瓣瓣膜膜片材料具有较强的生物力学性能,有望发展成为的一种较好的介入瓣瓣膜膜片材料。
The aim of this research is to investigate the preparation method of valve membrane in transcatheter bioprosthetic valve, and to study the effect of chemical modification and cutting technology to tensile property and suture force property of valve membrane. We carried out a series of processes to perform the tests, such as firstly to test the crosslinking degree of valve membrane using ninhydrin method, then to test the tensile property and suture force property by using Instron＇s biomechanical testing equipment, and then to observe the collagen fiber orientation in valve membrane using Instron＇s biomechanical testing equipment and using field emission scanning electron microscopy. The study indicated that after the chemical modification, the crosslinking degree, tensile strength and suture force strength increasing rate of valve membrane were 93.78%±3.2%, （8.24± 0.79） MPa, 102%, respectively. The valve membrane had a better biomechanical property and would be expected to become valve membrane in transcatheter bioprosthesis valve.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2014年第4期801-805,共5页
Journal of Biomedical Engineering
基金
中国博士后科学基金资助项目(2011M500798)
上海市博士后科研资助计划重点项目资助(12R21421800)
上海市国际科技合作基金资助项目(10440707000)
关键词
介入瓣
瓣膜膜片
碳化亚胺
缝合力
transcatheter bioprosthetic valve
valve membrane
carbodiimide
suture force
