摘要
目的探索百部的药理作用,评价其有效性,为临床应用提供依据。方法分别采用小鼠氨水引咳法观察百部的止咳作用,在体豚鼠喷雾致喘法观察百部的平喘作用,大鼠毛细管排痰实验观察百部的祛痰作用,小鼠耳壳肿胀法观察百部的抗炎作用,小鼠常压耐缺氧实验观察百部的抗应激作用。结果百部能延长小鼠浓氨水引咳的潜伏期,减少咳嗽次数;增加大鼠毛细管排痰量;对乙酰胆碱和组胺所致豚鼠呼吸困难无显著缓解,不能有效延长引喘潜伏期;对二甲苯所致小鼠耳廓炎症有一定抑制作用;对小鼠常压缺氧耐受力无明显影响。结论百部具有良好的止咳、化痰作用和较弱的抗炎作用。
Objective To observe the pharmacological actions of radix stemonae ,evaluate its effective-ness and to provide the basis for its clinical application .Methods Coughing mice induced by ammonia water was used to study the antitussive effect of radix stemonae .The asthma model in vivo guinea pig was used to observe the antiasthmatic effect of radix stemonae .The effect of eliminating phlegm on rat capillary was observed .The anti-inflammatory effect on external ear swelling model was also observed .The hypoxia tol-erance experiment on mouse was used to observe anti-stress effect of radix stemonae .Results s Stemona could prolong the incubation period of cough induced by ammonia ,decrease the frequency of cough ,in-crease the amount of the rat dispelling phlegm .No significant response to breathing difficulties occurred in guinea pigs induced by histamine and acetylcholine ,but could not effectively prolong the incubation period of asthma .It had certain inhibition effect on the ear inflammation induced by Xylene ,but no obvious effect on the hypoxic stress tolerance in mice .Conclusion Radix stemonae has antitussive effect ,the phlegm re-duction effect and weak anti-inflammatory effect .
出处
《山东医学高等专科学校学报》
2014年第3期197-200,共4页
Journal of Shandong Medical College
关键词
百部
动物实验
药效学
Radix Stemonae
Animal testing
Pharmacodynamics
