摘要
目的探讨基质金属蛋白酶-9(MMP-9)、组织金属蛋白酶抑制剂-1(TIMP-1)与血流变学指标的相关性。方法选择2型糖尿病脑梗死患者56例(A组),非糖尿病脑梗死患者49例(B组)及健康男性40例(C组),分别检测血清MMP-9、TIMP-1水平,并进行血流变学指标检测。结果 A组MMP-9、MMP-9/TIMP-1显著高于B、C组,TIMP-1较C组显著下降,差异均有统计学意义(P<0.05)。B组MMP-9及MMP-9/TIMP-1较C组显著升高,差异也有统计学意义(P<0.05)。A组高切黏度、血浆比黏度、血小板聚集指数较B、C组差异有统计学意义(P<0.05),B组低切黏度、血浆比黏度、血小板聚集指数较C有差异也有统计学意义(P<0.05)。MMP-9与高切黏度、血浆比黏度、血小板聚集指数呈正相关(P<0.05)。TIMP-1与高切黏度、血浆比黏度呈负相关(P<0.05)。MMP-9/TIMP-1与高切黏度、低切黏度、血浆比黏度、血小板聚集指数均存在相关性(P<0.05)。结论男性糖尿病脑梗死患者MMP-9、TIMP-1及其比值与血流变学指标有一定的相关性,这些指标的测定有助于糖尿病脑梗死的诊断。
Objective To investigate the correlation of matrix metallopeptidase-9 （MMP-9 ）and tissue inhibitor of metalloprotei-nase-1（TIMP-1）with hemorrheology in male patients with diabetic cerebral infarction.Methods 56 patients with type 2 diabetic cerebral infarction（group A）,49 cases with non-diabetic cerebral infarction（group B）,and 40 cases of community healthy men （group C）were enrolled in the study.The serum levels of MMP-9 and TIMP-1 and hemorrheology indexes were detected.Results The levels of MMP-9 and MMP-9/TIMP-1 in group A were significantly higher than those in group B and C（P〈0.05）,however, TIMP-1 level in group A was significantly lower than that of group C（P〈0.05）.The levels of MMP-9 and MMP-9/TIMP-1 in group B existed significant increasing,compared with group C（P〈0.05）.The levels of high shear viscosity,plasma viscosity,and platelet aggregation index in group A were significantly higher than those in group B and C（P〈0.05）.While the levels of low shear viscosity,plasma specific viscosity,and platelet aggregation index showed significant differences between group B and C（P〈0.05）. MMP-9 positively correlated with high shear viscosity,plasma specific viscosity,and platelet aggregation index（P〈0.05）.TIMP-1 negatively correlated with high shear viscosity and plasma ratio viscosity（P〈0.05）.And MMP-9/TIMP-1 showed significant cor-relation with high shear viscosity,low shear viscosity,plasma specific viscosity,and platelet aggregation index（P〈0.05）.Conclusion In patients with diabetic cerebral infarction,MMP-9,TIMP-1 and their ratio show some correlation with hemorrheology indexes. Detecting these indexes would be helpful for the diagnosis of diabetic cerebral infarction.
出处
《国际检验医学杂志》
CAS
2014年第12期1583-1584,1587,共3页
International Journal of Laboratory Medicine
