摘要
目的探讨检测血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)在慢性阻塞性肺疾病急性加重(AECOPD)患者诊疗中的意义。方法选择45例AECOPD患者(AECOPD组)及50例慢性阻塞性肺疾病(COPD)稳定期患者(COPD组),分别测定其PCT、hs-CRP和WBC。结果治疗前AECOPD组的PCT、hs-CRP分别为(3.32±1.81)ng/mL和(22.36±5.03)mg/L,明显高于COPD组,差异有统计学意义(P<0.01)。AECOPD组的PCT、hs-CRP阳性率诊断为68.9%和60.0%,均高于COPD组,差异有统计学意义(P<0.01)。AECOPD患者经抗菌药物治疗后PCT、hs-CRP、WBC较治疗前显著降低,差异有统计学意义(P<0.01)。结论在AECOPD患者中,PCT和hs-CRP是较好的诊断指标。
Objective To evaluate the clinical significance of detection of serum procalcitonin（PCT）,high sensitivity-C-reactive protein（hs-CRP）and leukocyte in acute exacerbation of chronic obstructive pulmonary disease（AECOPD）patients.Methods 45 patients with AECOPD and 50 patients（AECOPD group）with chronic obstructive pulmonary disease（COPD）in slationary phase （COPD group）were selected,and their serum levels of PCT,hs-CRP and leukocyte were tested.Results Before treatment,the con-centrations of PCT and hs-CRP were （3.32±1.81）ng/mL and （22.36±5.03）mg/L in AECOPD group respectively.They were significantly higher than those in COPD group with statistical differences（P〈0.01）.The positive predictive value of PCT and hs-CRP was 68.9% and 60.0% in AECOPD group respectively,which were significantly higher than those in COPD group（P〈0.01）.After antibiotic treatment,the leukocyte,PCT,and hs-CRP levels in AECOPD group were significantly lower than those be-fore treatment（P〈 0.01）.Conclusion In AECOPD patients,PCT and hs-CRP are good diagnostic indexes.
出处
《国际检验医学杂志》
CAS
2014年第12期1573-1574,共2页
International Journal of Laboratory Medicine
关键词
降钙素原
C反应蛋白
慢性阻塞性肺病
细菌感染
procalcitonin
C reactive protein
chronic obstructive pulmonary disease
bacterial infection
